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Family Schizaeceae / Lygodiaceae

Nitong-puti
Lygodium flexuosum Swartz.

MAIDENHAIR CREEPER

Scientific names  Common names 
Lygodium flexuosum Swartz. Katak (Ibn.) 
Ophioglossum flexuosum Nitong-puti (Tag.)
  Nito-a-dadakkel (Ilk.)
  Nitu (Ibn.)
  Kakulung (Ibn.)
  Kakulung (Ibn.)
  Sasitang (Ilk.)
  Nito nga purao (Ilk.)
  Climbing fern (Engl.)
  Maidenhair creeper (Engl.)
Nito's varieties of common names is confusingly shared among four species of plants belonging to the Family Schizaeceae / Gemus Lygodium: (1) Nito, Lygodium circinnatum, nitong puti, nitoan (2) Nitong puti, Lygodium flexuosum, nito nga purao (3) Nitong-pula, Lygodium japonicum, nito, nito-a-purao (4) Nito-nitoan, Lygodium scandens, nitong parang, nito.

Botany:
Lygodium flexuosum is a climbing or scrambling fern. Pinnae are pinnate, 15 to 25 cm long, and sometimes bipinnate in the lower part. Pinnules are stalked, finely serrate, otherwise entire lanceolate or more commonly lobed on both sides at the base, 4 to 10 cm long; the fertile pinnae are shorter than the sterile one. Spikes are 2 to 10 mm long. Spores are verruculose.

Distribution
Common and widely distributed, especially in open places in the Philippines.

Parts utilized
Roots and leaves.

Constituents
Plant yields antheridiogens, lygodinolide, O-P-coumaryldryocrassol, tectoquinone, kaempferil, kaemferol-3-beta-D-glucosdie, beta-sitosterol and stigmasterol as main constituents.

Properties
Considered antioxidant, anti-implantation, anti-ovulatory.

Uses
Edibility
In Nepal, during times of scarcity, Chitwan people use it as vegetable sustenance.
Folkloric
Roots and leaves used externally for ringworm and other skin ailments.
Elsewhere, plant is used in treatment of blenorrhagia.
In Indian traditional medicine, used for liver disorders.
The Maharashtra tribe in India smoke bidi made of roots for rheumatism and arthritis; also, fresh roots boiled with mustard oil used for massage. Bidi also smoked for bleeding gums, bad breath, sprains, scabies, rheumatism, as antifertility and abortifacient, for jaudice and wound healing.
In Nepal, plant ash used for herpes.

Others
Animals: Plant fed to domestic animals to treat foot and mouth diseases.

Studies
Hepatoprotective Effect: (1) Rats treated with extracts of Lygodium flexuosum after establishment of carbon tetrachloride induced liver injury showed significant protection of the liver as evidenced by AST, ALT, LDH and MDA levels. Phytochemical study yielded saponins, triterpenes, sterols and bitter principles which could explain the possible hepatoprotective action. (2) Results suggest L. flexuosum exerts effective protection in carbon tetrachloride induced hepatic fibrosis in rats.
Chemopreventive Effect / Antiproliferative/ Apoptotic: Study showed L flexuosum extract has antiproliferative and apoptotic activity in cancer cells and has inhibitory role in TNF-alpha induced NF-kappaB activation in PLC/PRF/5 cells confirmings its potential as a chemopreventive agent.
Antiangiogenic / Hepatoprotective: Study of antiangiogenic effect of L. flexuosum in NDEA-intoxicated Wistar rats in preventive and curative models showed the LFE reversed the hepatoxicity induced by N-nitrosodiethylamine in both experimental models.
Phenolic Content / Antioxidant: In vitro antioxidant activity of different extracts of LF were evaluated in different models. Highest phenolic content was found in the methanolic extract (6.24%) with the highest antioxidant activity.

Availability
Wild-crafted. 

Last Update April 2011

Photos © Godofredo Stuart / StuartXchange
OTHER IMAGE SOURCE: Lygodium flexuosum /Lowe Antique Prints of Ferns 1856 / Panteek

Additional Sources and Suggested Readings
(1)
Protective effect of Lygodium flexuosum (L.) Sw. extract against carbon tetrachloride-induced acute liver injury in rats / P J Wills, V V Asha / Journal of Ethnopharmacology • 01/01/2007; 108(3):320-6 / DOI: 10.1016/j.jep.2006.05.032
(2)
Chemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells / Willis P J / Journal of Ethnopharmacology, 2009, 122 (2): p. 294-303 /

(3)
TRADITIONAL USES OF PLANTS OF COMMONLAND HABITATS IN WESTERN CHITWAN, NEPAL / D R Dangol / J. Inst. Agric. Anim. Sci. 29:71-78 (2008)
(4)
Antiangiogenic effect of Lygodium flexuosum against N-nitrosodiethylamine-induced hepatotoxicity in rats

/ PJ Wills, V Suresh et al / Chemico-Biological Interactions, Vol 164, Issues 1-2, 1 December 2006, Pages 25-38 / doi:10.1016/j.cbi.2006.08.021
(5)
CORRELATION OF ANTIOXIDANT ACTIVITY WITH PHENOLIC CONTENT AND ISOLATION OF
ANTIOXIDANT COMPOUND FROM LYGODIUM FLEXUOSUM (L.) SW. EXTRACTS
/ Nehete Jeetendra, Bhatia Manish / International Journal of Pharmacy and Pharmaceutical Sciences, Vol 3, Issue 2, 2011
(6)
Preventive and curative effect of Lygodium flexuosum (L.) Sw. on carbon tetrachloride induced hepatic fibrosis in rats / PJ Willis and VV Asha / Journal of Ethnopharmacology, Volume 107, Issue 1, 11 August 2006, Pages 7-11 / doi:10.1016/j.jep.2006.01.031
(7)
Studies on plants used in traditional medicine by Bhilla tribe of Maharashtra / Indian Journ of Traditional Knowledge, Vol 9 (3), July 2010, pp 591-598.


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