Botany
Pakopatoti-alog is a hairy, branched herb, spreading from the roots and growing up to 70 cm high. Buds are white and wooly. Leaves are alternate, stalkless, sinuately pinnatifid, and divided into toothed lobes. Flowering heads are borne opposite the leaves, and are short-peduncled, rounded, and 8 to 10 mm in diameter.

Distribution
An occasional weed in open, waste places in and about towns.
In La Union, Pampanga, Bulacan and Rizal Provinces in Luzon.
Introduced, also occurring in tropical and subtropical Asia and Africa.

Constituents
- Study isolated a diterpenoid from the acetone extract - 8-hydroxy-13E-labdane-15yl-acetate.
- Study of the whole plant isolated two new 5-deoxyflavones, 6-hydroxy-2′,4′,5′-trimethoxyflavone and 6-hydroxy-3′,4′,5′-trimethoxyflavone, together with a known flavone, 7,2′,4′-trimethoxyflavone.

Properties
Analgesic, stomachic, antispasmodic.

Parts used
Leaves.

Uses
Folkloric
In the Philippines, leaf infusion used as stomachic and antispasmodic.
In India leaves are a valuable stomachic with deobstruent and antispasmodic properties. Also, presribed as an infusion and electuary for obstructed menses and hysteria.
Leaves somestimes used in antiseptic and anodyne preparations.
Others
Others

Studies
• Analgesic: Study of methanol extract of the whole plant of Grangea maderaspatana showed a dose-dependent analgesic activity.
• Antioxidant / Free Radical Scavenging: Study showed antioxidant acitivity that was concentration dependent, increasing with the amount of extract. Free radical scavenging and antioxidant activities may be attributed to the presence of phenolic and flavonoid compounds.
• Estrogenic / Anti-implantation Efficacy: A mixture of flavonoids extracted from G. maderaspatana showed oestrogenicity and antiimplantational activities in a mouse study.
• Studies: Studies

Availability
Wild-crafted.

Additional Sources and Suggested Readings
(1)
A preliminary study on the analgesic activity of Grangea maderaspatana / Ahmed M, Islam MM, Hossain CF, Khan OF / Fitoterapia. 2001 Jun;72(5):553-4.
(2)
Free Radical Scavenging Activity of Grangea maderaspatana Poir. / Veena Patel, Sangita Shukla, Sandip Patel / Pharmacognosy Magazine, Vol. 5, No. 20. (2009), pp. 381-387
(3)
A diterpene from Cipadessa fruticosa and Grangea maderaspatana / S R Rohatkar et al / Phytochemistry
Volume 37, Issue 4, 7 November 1994, Pages 1213-1214 / doi:10.1016/S0031-9422(00)89562-X
(4)
Oestrogenic and pregnancy interceptory efficacy of a flavonoid mixture from Grangea maderaspatana poir (Artemisia maderaspatana) in the mouse / Sunita Jain, Vineeta Sareen, Anita Narula / Phytotherapy Research, Vol 7, Issue 5, pages 381–383, September/October 1993 / DOI: 10.1002/ptr.2650070512
(5)
Two new bio-active flavones from Grangea maderaspatana (Artemisia maderaspatana) / V Rao, G Damu et al / Asian Journal of Chemistry 2009 Vol. 21 No. 2 pp. 1552-1558