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Family Verbenaceae / Lamiaceae
Alagaw
Premna odorata Blanco

FRAGRANT PREMNA

Alagau is a shared common name for: (1) Magilik, alagau (P. Bis.), Premna cumingiana (2) Alagau-gubat, Premna nauseosa and (3) Alagau, Premna odorata.
The Quisumbing compilation lists Premna serratifolia as a synonym of Premna odorata; other data bases list it as a synonym of Premna integrifolia.

Other scientific names  Common names  
Premna curranii H. Lam.  Abgau (P. Bis.) Atiñgi (Gad.)
Premna oblongata Miq,   Adgau (P. Bis., Bik.) Duragau (Sub.)
Premna pubescens Blume  Adiyo (Tag.) Guachal (Ig.) 
Premna serratiflolia Blanco  Aggau (C. Bis.) Lagau (Mag.) 
Premna vestita Schauer  Alagau (Tag., Ilk.) Lassi (Ibn.) 
  Anobran (Ilk.) Pumuhat tangli (Pang.) 
  Argau (P, Bis.) Tibangñgen (Bon.) 

Botany
Small hairy tree, 3 to 8 meters high. Leaves are ovate to broadly ovate, 10-20 cm long, with broad, rounded, or heart-shaped base and pointed tips. The under surface of the blade is usually covered with short hairs, aromatic when crushed. Flowers are greeninsh-white or nearly white, 4-5 mm long and borne on terminal inflorescences (cymes) 68-20 cm in diamter. Fruit is fleshy, dark purple, rounded, about 5 mm diameter.

Distribution
In thickets and secondary forests at low altitudes.

Chemical constituents and properties
Leaves do not contain alkaloid, tannin, saponin or cyanogenetic substance.
Leaves yield 0.02 percent yellowish-green essential oil with a characteristic scent.
Sudorific, pectoral, carminative.


Parts utilized
Leaves and flowering tops, fresh or dried.

Uses
Folkloric
· Cough: Sugared decoction of leaves as tea helps loosen up phlegm.
• Decoction of leaves for fever and colds, cough and bronchitis.
· Flatulence (gas pains):
     Adults: decoction of leaves as tea.
     Children: Crush leaves, mix with a little coconut or cooking oil and apply on abdomen.
· Headache: Crush leaves and apply on forehead and temples.
·Tea decoction of the leaf has been used for tuberculosis.
· Chewing the roots believed to have cardiac benefits.
· Decoction of shoots used as paraciticide.
· Decoction of leaves used for bathing infants.
• Decoction of fresh leaves used for vaginal irrigation.
· Extract of leaves for cleaning wounds and for ticks and fleas.
· Leaves applied over the bladder facilitates urination.
Culinary
Young leaves used in the cooking of "paksiw" and "bopis."
New
• Decoction of leaves and flowering tops used as vaginal wash or douche; antiseptic properties make it useful for cleansing and incorporation with bath-care products.
Pito-pito: Leaves are one of the seven ingredients of the popular herbal Filipino tea blend – alagaw, banaba, bayabas, pandan, manga, anis and cilantro. (See: Pito-Pito)

Studies
• Collagen Network / Acetoside:
Study of methanol extract of leaves of Premna odorata exhibited a promotion of collagen network formation by M cells and isolated acetoside, an phenylethanoid with a variety of biological activities. Acetoside may contribute to wound healing.
• Anti-Viral Activity: Study of 61 medicinal plants in Malaysia showed P odorata was 1 of 11 plants to show selective activity against vesicular stomatitis (VSV) viruses.
• In-vitro Photo-Cytotoxic Activity: A study of 155 extracts from 93 species of plants in Malaysia screened for in vitro photo-cytotoxic activity using a human leukemia cell lin, P odorata was one of 29 plants that was able to reduce in vitro cell viability by more than 50% when exposed to broad spectrum light.
• Hepatoprotective / Cytotoxic Activity: Study showed the alcoholic extract with significant hepatoprotective activity evidenced by decrease of serum enzymes, bilirubin and lipid peroxidation, comparable to drug silymarin. It also exhibited significant in-vitro cytotoxic activity. Results showed the alcoholic extract not only as an effective hepatoprotective agent, but with also significant antitumor activity.
• Antiparasitic Activity:
In a study of 18 medicinal plants in New Caledonia evaluated in vitro against several parasites, Scaevola balansae and Premna serratifolia were the most active against Leishmania donovani.

Availability
Wild-crafted.
 



Additional Sources and Suggested Readings
(1)
A Collagen Network Formation Effector from Leaves of Premna subscandens / September 1999 / Hirokazu SUDO, Kaori KIJIMA et al / Chem. Pharm. Bull. 47(9) 1341—1343 (1999)

(2)
Antiviral and Cytotoxic Activities of Som.e Plants Used in Malaysian Indigenous Medicine / Ali, Abdul Manaf and Mackeen et al / Pertanika J. Trop. Agric. Sci., 19 (2/3). pp. 129-136.
(3)
Systematic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy / Cheng Yi Ong et al / Journal of Photochemistry and Photobiology B: Biology • Volume 96, Issue 3, 4 September 2009, Pages 216-222 / doi:10.1016/j.jphotobiol.2009.06.009
(4)
Evaluation of Hepatoprotective and In-vitro Cytotoxic Activity of Leaves of Premna serratifolia Linn / R Vadivu et al / J. Sci. Res. 1 (1), 145-152 (2009)
(5)
Antiparasitic activity of some New Caledonian medicinal plants / Julie Desrivot et al / Journal of Ethnopharmacology • Volume 112, Issue 1, 30 May 2007, Pages 7-12 / doi:10.1016/j.jep.2007.01.02


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