Family Anonaceae
Atis
Anona squamosa Linn.
SUGAR APPLE

Common names
Ates (Tag.) 
Atis (Tag.) 
Yates (Tag.)
Sugar apple (Engl.)
Sweetsop (Engl.)

Botany
Small tree. 3 to 5 meters high. Leaves are hairy when young, oblong, 8 to 15 cm long, with a petiole 1 to 1.5 cm long. Flowers occur singly in the axils of the leaves, about 2.5 cm long, pendulous, three-angled, light green to yellow. Fruit is large, slightly heart-shaped, 6 to 9 cm long, the outside with knobby polygonal tubercles. When ripe, the fruit is light yellowish-green, with a white, sweet soft, delicious and juicy flesh.

Distribution
Cultivated throughout the Philippines; occasionally spontaneous.

Parts used and preparation
Leaves, fruit and seeds.

Chemical constituents and properties
The leaves yield an alkaloid, chloroplatinate.
Anonaine, an alkaloid, is found in the bark, leaves and seeds.
Seed yields an alkaloid, neurtral resin, fixed oil.
Seed contains a yellow, non-drying oil and an irritant which kills lice.
The leaves, fruit and seeds are vermicidal and insecticidal.
The unripe fruit is astringent, used for diarrhea and dysentery and dyspepsia.
The bark is astringent and tonic.
Roots make a drastic purgative.
Leaves are emmenagogue, febrifuge, tonic
Insecticide, antiovulatory, abortifacient.

Uses:
Folkloric
Salted bruised leaves used to hasten suppuration.
Bark decoction is used as tonic and to stop diarrhea.
Root has purgative action.
Leaf decoction used for rheumatic baths to alleviate pain.

For fainting and hysteria, crush fresh leaves and place over nose.
For infected insect bites, pound and extract the juice from one unripe fruit and apply the juice directly to the affected areas, 3 times daily.
For lice infestation of the head, atis has a herbal treatment regimen:
(1) Shampoo hair with gugo bark or any commercial shampoo daily for one week; with "suyod" combing twice daily.
(2) For lice eggs (nits), apply hot vinegar for half an hour after shampooing; then "suyod" (fine combing) thoroughly.
(3) Bedtime, pound 1/2 cup of atis seeds and mix with 1/4 cup of oil. Apply mixture throroughly to the scalp and hair. Wrap the hair and head overnight. Shampoo in the morning and follow with fine tooth combing. Do daily for 3-5 days.
(4) Paste of the crushed seeds in water, applied to the scalp. The same used as abortifacient applied to the os uteri.
Nutrition
Eaten raw or makes a delicious ice cream.
The fermented fruit used to make cider.
Others
The blackened aborted atis fruit is a preferred by some healers as an ingredient in the making of the "unton," used for bales.

Studies
Studty on the anti-inflammatory effects of seed oils of Annona species.
Isolation of antibacterial and anti-inflammatory kaurane-type diterpenese.
Antitumor constituents from Annona squamosa fruit pericarp: The chloroform extract of the pericarp was found to be cytotoxic to different cell lines tested. Study showed the potential of Anona squamosa fruit pericard for the development of medicine for the treatment of cancers.
Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats: Study results showed that A. squamosa extract has an antihyperglycemic effect and alleviated liver and renal damage associated with STZ-induced diabetes mellitus in rats.
Mono-tetrahydrofuran Annonaceous Acetogenins from Annona squamosa as Cytotoxic Agents and Calcium Ion Chelators: Squadiolins A and B showerd potency against human Hep G2 and 3B hepatoma and MCF-y breast cancer cells.
Availability
Wild-crafted.
Small or large scale cultivation for fruit produce.
 


Additional Sources and Suggested Readings
(1)
Antitumor constituents from Annona squamosa fruit pericarp / Beena Joy1 and P. Remani2
(2)
Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats / Kaleem M, Medha P, Ahmed Q U, Asif M, Bano B
(3)
Mono-tetrahydrofuran Annonaceous Acetogenins from Annona squamosa as Cytotoxic Agents and Calcium Ion Chelators /Chih-Chuang Liaw, Yu-Liang Yang, Mei Chen, Fang-Rong Chang, Shu-Li Chen, Shih-Hsiung Wu and Yang-Chang Wu


Additional Sources