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Family Fabaceae
Balatong-pula
Tephrosia purpurea (Linn.) Pers.
PURPLE TEPHROSIA

Hui mao dou

Scientific names Common names
Tephrosia purpurea (Linn.) Pers. Balatong-pula (Tag.)
Tephrosia piscatoria (Dryand.) Pers. Balbalatong (Tag.)
Cracca purpurea L. Fish poison (Engl.)
  Purple tephrosia (Engl.)
  Wild indigo (Engl.)
  Hui mao dou (Chin.)



Botany
Balatong-pula is a copiously branched, suberect, slender, herbaceous perennial. Stems are smooth or finely downy, 30 to 60 centimeters in height. Leaves are odd-pinnate, 7.5 to 15 centimeters long, with 13 to 21 leaflets which are narrow and oblanceolate. Racemes are long, all leaf-opposed, and 7.5 to 15 centimeters in length. Lower flowers are fascicled. Calyx is covered with silky hair, has narrow teeth, and is as long as the tube. Corolla is red. Pods are 3.5 to 5 centimeters long and slightly recurved, containing 6 to 10 seeds.

Distribution
- In open grasslands or waste places at low altitudes.
- In Cavite and Batangas Provinces in Luzon; and in Bukidnon and Misamis Provinces in Mindanao.
- Also occurs in India to southern China through Malaya to tropical Australia.

Constituents
- Leaves yielded a glucoside, rutin, 2.5 %.
- Study of aerial parts yielded an aromatic ester, a sesquiterpene and a prenylated flavonoid.
- Plant also yields chalcones and rotenoids.
- Seed extracts yielded alkaloids, flavonoids, carbohydrates, proteins, amino acids, tannins, phenolic compounds, saponins, steroids, sterols, triterpenoids and fixed oil.

Properties
- Plant is considered cooling, deobstruent, cordial, diuretic, laxative and tonic; internally as blood purifier.
- Root is bitter.

Parts used
Roots, seeds, leaves and bark.

Uses

Folkloric
- Used for coughs, tightness of the chest, bilious febrile attacks, obstructions of the liver, spleen and kidneys.
- Recommended as blood purifier, for boils and pimples.
- Roots used for dyspepsia and chronic diarrhea.
- Infusion of seeds used as cooliing medicine.
- Decoction of pounded leaves used for snake bites.
- In Ceylon, used as anthelmintic for children.
- In Punjab, infusion of seeds considered cooling.
- In Sri Lanka, decoction of roots used as nematicide for treatment of Toxocara canis larvae which causes lung disease. Also used for colic, diarrhea and dyspepsia, and as anthelmintic.
- Fresh root-bark, ground and made into a pill, mixed with a little black pepper, used for obstinate colic.
- In traditional Indian medicine, a common ingredient of formulations for liver ailments. Also, used for bilious febrile attacks, liver and splenic affections, cirrhosis and hepatitis.
- Oil from seeds used for scabies, eczematous itching, and other skin eruptions.
- Used for piles, syphilis and gonorrhea.
Others
- Leaves used as fodder in India and South Africa.
- In India, grown as green manure in paddy fields.
- In India, dry plants collected as fuel.
- Seeds used as substitute for coffee.
- Used as insect repellent.


Studies
Modulatory Effect / Chemopreventive:
Study results suggest that T. purpurea is an effective chemopreventive agent in the skin that may suppress benzoyl peroxide-induced cutaneous toxicity.
Immunomodulatory : The flavonoid fraction of Tephrosia purpurea significantly inhibited sheep RBCs-induced delayed type-hypersensitivity reactions and significantly dose-dependently reduced hemagglutination antibody titer. Results of the study in mice indicate the ability to modulate both cell-mediated and humoral components of the immune system.
Antihyperglycemic / Antioxidant: Study of the ethanolic seed extract clearly indicated potent antihyperglycemic and anti-lipid peroxidative effects in streptozotocin-induced diabetic rats.
Antibacterial: The ethanolic root extract of Tephrosia purpurea showed significant activity against Pseudomonas aeruginos, two other pseudomoas strains and two coliform strains.
Hepatoprotective: Study in albino rats evaluating the hepatoprotective activity of aerial parts of T purpurea and stem bark of T undulata against thioacetamide-induced hepatotoxicity showed significant reduction of serum enzymes and other chemical indices, significant improvement in liver glutathione, and dose-dependent reduction of necrosis on histopath exam.
Antioxidant: Study showed the leaves of T purpurea have antioxidant potential. The ethanolic extract showed to be more portent than the aqueous decoction. The antioxidant content may be responsible for its use in the treatment of jaundice and other oxidative stress-related diseases.
Renal Protective: Study evaluated the protective and curative effects of TP extracts on gentamicin-induced acute renal injury in albino rats. Results showed the ethanol extract of leaves possess marked nephroprotective and curative activities without toxicity. The mechanisms of activities were attributed to phenolic and flavonoidal compounds like quercetin. Results suggest a promising role for TP in the treatment of acute renal injury caused by pharmaceutical nephrotoxins.
Wound Healing: (1) Histopathological study of wound healing potential using three types of wound models in rats (incision wound, excision wound and dead space wound) showed significant increase in fibroblast cells, collagen fibers and blood vessels formation. (2) Flavonoid-rich fraction of aerial parts of Tephrosia purpurea showed a potential for enhancing the burn wound healing process, probably through to its free radical scavenging property.
Anticarcinogenic / Anti-Lipid Peroxidative: Study showed the ethanolic root extract has potent chemopreventive efficacy and significant anti-lipidperoxidative effect, in DMBA-induced oral carcinogenesis.
Anti-Ulcer Healing: Study showed the aqueous extract of roots of Tephrosia purpurea possess significant anti-ulcer property which could be due to a cytoprotective action of the drug or through a strengthening of the gastric and duodenal mucosal and enhancing of mucosal defense mechanisms.
Phytochemical / Antimicrobial: Study showed a pet ether extract to have the most potent antimicrobial activity against gram positive, gram negative bacteria and Candida albicans.
Antihyperglycemic / Antihyperlipidemic: Study of aqueous extract of leaves showed prominent antihyperglycemic and hypolipidemic effects in streptozotocin-induced diabetic rats.
Anti-Inflammatory / Analgesic: Study of an ethanol extract of aerial and root parts of T. purpurea in rats showed dose-related anti-inflammatory and analgesic activities.

Availability
Wild-crafted.

Last Update September 2011

IMAGE SOURCES: Tephrosia purpurea var. purpurea / Seed pod at LaPerouse, Maui / Forest & Kim Starr - Plants of Hawaii / Creative Commons Attribution / AlterVISTA (2) GNU Free Documentation License / Unhali, Sarphonk, Wild Indigo / J M Garg / 7.09.08 / - Wikimedia Commons
OTHER IMAGE SOURCES: Unhali, Sarphonk, Wild Indigo / J M Garg / 7.09.08 / GNU Free Documentation License / Wikimedia Commons
OTHER IMAGE SOURCES: Tephrosia purpurea (L.) Pers. - fishpoison / Tracey Slotta @ USDA-NRCS PLANTS Database / USDA

Additional Sources and Suggested Readings
(1)
Tephrosia purpurea Ameliorates Benzoyl Peroxide-induced Cutaneous Toxicity in Mice: Diminution of Oxidative Stress / Mohammad Saleem, Aftab Alam et al / Pharmacy and Pharmacology Communications
Volume 5, Issue 7, pages 455–461, July 1999 / DOI: 10.1211/146080899128735162
(2)
Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea / A S Damre, A B Gokhale et al /
Fitoterapia, Vol 74, Issue 3, April 2003, Pages 257-261 / doi:10.1016/S0367-326X(03)00042-X
(3)
ANTIHYPERGLYCEMIC AND ANTILIPIDPEROXIDATIVE EFFECTS OF TEPHROSIA PURPUREA SEED EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS / P. Pavana, S.Sethupathy and S. Manoharan / Indian Journal of Clinical Biochemistry, 2007, 22 (1) 77-83.
(4)
Antibiotic Activity of Tephrosia purpurea (Fabaceae) and Mimusops elengi (Sapotaceae) against Some Clinical Bacterial Isolates / B.N.L.D. Rangama, C.L. Abayasekara and G.J. Panagoda / Proceedings of the Peradeniya University Research Sessions, Sri Lanka, Vol.12, Part I, 30thNovember 2007
(5)
Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata / Khatri A, Garg A, Agrawal SS / J Ethnopharmacol. 2009 Feb 25;122(1):1-5. Epub 2008 Nov 18.
(6)
Determination of polyphenols and free radical scavenging activity of Tephrosia purpurea linn leaves (Leguminosae) / Avani Patel, Amit Patel, Amit Patel, NM Patel / Pharmacognosy Research, 2010, Vol 2 No 3, Pp 152-158.
(7)
Effect of Tephrosia Purpurea Pers on Gentamicin Model of Acute Renal Failure / Avijeet Jain and A. K. Singhai / 13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING
IFMBE Proceedings, 2009, Volume 23, Track 4, 1438-1442, DOI: 10.1007/978-3-540-92841-6_355
(8)
Wound healing potential of Tephrosia purpurea (Linn.) Pers. in rats / Santram Lodhi, Rajesh Singh Pawar et al / Journal of Ethnopharmacology, Volume 108, Issue 2, 24 November 2006, Pages 204-210
/ doi:10.1016/j.jep.2006.05.011
(9)
Anticarcinogenic and antilipidperoxidative effects of Tephrosia purpurea (Linn.) Pers. in 7, 12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinoma / K Kavitha, S Manoharan / Indian Journ of Pharmacology, 2006, Vol 38, Issue 3, Page : 185-189 / doi:10.4103/0253-7613.25805
(10)
ANTIULCER ACTIVITY OF TEPHROSIA PURPUREA IN RATS / S.S. DESHPANDE, G.B. SHAH, N.S. PARMAR / Indian Journal of Pharmacology 2003; 35: 168-172
(11)
Chemical constituents of Tephrosia purpurea / Ali K Khalafalah, Afifi H Yousef, Abeer M Esmail et al / Pharmacognosy Res. 2010 Mar-Apr; 2(2): 72–75. / doi: 10.4103/0974-8490.62951
(12)
PHYTOCHEMICAL EVALUATION AND ANTIMICROBIAL ACTIVITY OF SEEDS OF TEPHROSIA PURPUREA LINN. / Mr. Sachin Parashram Venkatraman / Imperial J. Pharmaceutics & Cosmetology 1(1): June 2011
(13)
Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats / P. Pavana, S. Manoharan, G. L. Renju and S. Sethupathy / Journal of Environmental Biology October 2007, 28(4) 833-837 (2007)
(14)
Effect of Tephrosia purpurea (L) Pers. on Partial Thickness and Full Thickness Burn Wounds in Rats / Santram Lodhi, Rajesh Singh Pawar, Alok Pai Jain et al / Jour of Complementary and Integrative Medicine, Vol. 7 (2010) / Issue 1
(15)
Anti-inflammatory and analgesic activities of Tephrosia purpurea Linn. aerial and root extracts
/ Gopalakrishnan S, Vadivel E and Dhanalakshmi K /
Journal of Pharmacy Research, Vol 3, No 5 (2010)


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