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Family Asteracea
Damong-mabaho
Blumea lacera (Burm. f) DC.
MALAY BLUMEA

Scientific names Common names
Blumea lacera (Burm. f.) DC. Damong-mabaho (Tag.)
Conyza lacera Burm. f. Lamlampaka (Bon.)
Placus lacerus (Burm. f.) Kuntze Tubang-kabayo (Tag.)
Accepted Infraspecifics Malay blumea (Engl.)
Blumea lacera var. lacera Blumea (Engl.)
Blumea lacera var. subdivaricata J.Kost. False-ox tongue (Engl.)
Blumea lacera (Burm.f.) DC. is an accepted name. KEW: Plants of the World Online

Other vernacular names
CHINESE: Jian shuang huang.
BENGALI: Bara kukshima, Kukurmuta, Kukursunga, Shealmotra, Shealmoti, Fao ma (Marma).
GUJARATI: Kolhar.
HINDI: Jangli muli, Kukaraaundha.
MARATHI: Bhamurda, burando
TAMIL: Kattumullangi, Narakkarandai
TELUGU: Advimulangi, Karupogaku.
SANSKRIT: Kukkuradru, Kukundara, Mridu chhada, Tamrachuda.

Gen info
- Blumea is a genus of flowering plants of the family Asteraceae. Plants in the genus are mostly small weeds; some are ruderal  (growing on waste ground or among refuse) species. (47)

Botany
Damong-mabaho is a hairy or glandular, foetid herb, erect, simple or branched, very leafy, 30 to 60 centimeters in height. Leaves are obovate or oblanceolate, 5 to 12 centimeters long, 2 to 6 centimeters wide, smaller towards the top, stalked, and toothed or rarely lobulated at the margins. Flowering heads are about 8 millimeters across, borne on short axillary cymes, and collected in terminal, spikelike panicles. Involucre-bracts are narrow and hairy. Corolla is yellow and the pappus is white. Fruits are achenes, not ribbed, somewhat 4-angled and smooth.

Distribution
- Native to the Philippines.
- Widely distributed in open waste places at low and medium altitudes.
- Also native to Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China, Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Myanmar, Nepal, New Caledonia, New Guinea, New South Wales, Northern Territory, Oman, Pakistan, Queensland, Sri Lanka, Sulawesi, Sumatra, Taiwan, Thailand, Vietnam.
(48)

Constituents
- Study isolated two new glycosides, the triterpenoid glycoside 19α-hydroxyurs-12-ene-24,28-dioate and the phenol glycoside 2-isoprenyl-5-isopropylphenol from the whole plant of B. lacera.
- Essential oil contains cineol, fenchone.
- Leaves yield coniferyl alcohol derivatives, campesterol, and flavones.
- Ethanolic extract of aerial parts yields hentriacontane, hentriacontanol, α-amyrin, lupeol, and ß-sitosterol.
- Root and root bark yield triterpenes and sterols.
- Essential oil of leaves yielded thymoquinol dimethyl ether as main constituent, together with β-caryophyllene, α-humulene and E-β-farnesene. (9)
- Phytochemical characterization of the plant yielded alkaloids, steroids, terpenoids, cardiac glycosides, tannins, and phenolic compounds. (21)
- Phytochemical screening of aqueous, methanolic, and chloroform leaf extracts revealed the presence of secondary metabolites such as carbohydrates, alkaloids, phytosterols, steroids, phenolic compounds, tannins, flavonoids, cumarine, amino acids, terpenoids, and saponins. (see study below) (26)
- Study for essential oil yielded major compounds of 2,5-dimethoxy-p-cymene (28.7-o.4%),
ß-caryophyllene  (25.5-0.5%), carvotanacetone (24.5-0.4%), chrysanthenone (21.9-9.8%), and 2,6-dimethylphenol (11.4-1.8%). (see study below) (31)
- Study of ethanolic extract of whole plant isolated a flavonoid compound (1), 5-hydroxy-3'-methyl-3.6.7.4'-tetramethoxyflavone. (33)

  • Properties
    - Astringent, anthelmintic, antiscorbutic, febrifuge.
    - Essential oil considered analgesic, hypothermic and tranquilizing.
    - In Ayurveda, considered bitter, astringent, acrid, thermogenic, errhine, anti-inflammatory, styptic, ophthalmic, digestive, anthelmintic, tonic, expectorant, diuretic, deobstruent and stimulant.
    - Studies have shown antimicrobial, anti-leukemic, anti-inflammatory, repellent, antioxidant, antidiabetic, anti-bradykinin, anticancer, anthelmintic, tyrosinase inhibitory, antidiarrheal, antispasmodic, antiulcer, anxiolytic, hepatoprotective, antileukemic, antiviral, antipyretic, hepatoprotective, antinociceptive properties.

    Parts used
    Leaves, roots, flowers.

    Uses

    Edibility
    - Leaves cooked and eaten as vegetable.
    Folkloric
    - In the Philippines, a decoction of fresh flowers is given before meals for bronchitis - 30 gm in 1 liter of water, boiled to half of its volume.
    - Expressed juice of leaves used as anthelmintic, especially in cases of threadworm, either internally or applied locally. Used as a invaluable remedy for Tinea Tarsi.
    - Expressed juice of leaves, mixed with black pepper, given for bleeding piles. Also, used as febrifuge and astringent.
    - Dried herb used as febrifuge; as astringent in hemorrhages; as deobstruent and stimulant.
    - Astringent eye lotion prepared from the leaves.
    - Plant used as diuretic.
    - Useful for catarrhal affections, wound healing.
    - Used for treatment of inflammatory bowel disease.
    - In
    Ayurveda, used as a bitter, astringent, acrid, thermogenic, errhine, anti-inflammatory, styptic, ophthalmic, digestive, anthelmintic, liver tonic, expectorant, febrifuge, antipyretic, diuretic, deobstruent, and stimulant. (33)
    - In West Africa, plant prescribed as antiscorbutic.
    - In India, root kept in the mouth used for buccal diseases. Tincture used for bleeding piles.
    - In Uttar Pradesh, India, fresh leaf juice used twice daily for a week to treat threadworms. (22)
    - In Bangladesh, natives of Sudarban use the herb for treatment of bleeding piles. Leaves used to treat most kinds of colds. Warm leaf paste used as diuretic. Leaf paste with black pepper powder applied to dog bites. (
    30)
    Others
    - Repellent: In the Konkan region of India, plant used to drive away fleas and other insects.


    Studies
    Phytochemicals / Antimicrobial:
    Study of extract of air-dried leaves of Blumea lacera yielded α-pinene-7β-O-β-d-2,6-diacetylglucopyranoside, 5,4′-dihydroxy-6,7,3′-trimethoxyflavone, and 3,5,4′-trihydroxy-6,7,3′-trimethoxyflavone. Compounds 1-3 showed moderate activity against Candida albicans, low activity against Trichophyton mentagrophytes. (2)
    Cytotoxicity: Study of 16 Bangladeshi medicinal plants were studied for its cytotoxic effects. The methanolic extract of Blumea lacera showed the highest cytotoxicity against all tested cell lines, including three human cancer-cell lines (gastric, colon and breast). (3)
    Antibacterial: Study on the antibacterial activity of 5 indigenous plant species showed greater inhibitory effect against Gram-positive bacteria. The largest zone of inhibition was recorded against Bacillus subtilis with the leaf extract of Blumea lacera. (4)
    Tyrosinase Inhibitory Activity: A methanolic extract of B. lacera showed very good mushroom tyrosinase inhibitory activity. Tyrosinase inhibitors may provide clues for the development of new insect control agents, food additives and whitening agents. (8)
    Antidiarrheal: Study in experimental rats showed an ethanolic extract of root of B. lacera had more antidiarrheal activity than B. eriantha, although less effective compared with atropine sulfate. (10)
    Antioxidant: Study of methanol extracts of four Bangladesh medicinal plants, including B. lacera, showed antioxidant activity. BL also showed toxic action in the cytotoxicity assay against MDCK cell line. (11)
    Anthelmintic: Study evaluated the in vitro anthelmintic activity of Blumea lacera against Ascaris lumbricoides and Pheretima posthuma with piperazine citrate as standard. Results showed good dose dependent anthelmintic activity. (12)
    Hypoglycemic / Leaves: Study evaluated the hypoglycemic activity of methanolic extract of B. lacera leaves on Swiss albino mice, with glibenclamide as standard. Treatment of leaf extract on glucose-loaded hypoglycemic mice lead to significant reduction of blood glucose levels in a dose dependent manner. Results showed significant hypoglycemic activity supporting its traditional use. (13) (27)
    Antioxidant / Toxicological Study: Bangladesh study evaluated four plants--A. capillus-veneris, Blumea lacera, C. alata, and Cissus quadrangularis for antibacterial and antioxidant (DPPH assay) potentials, together with toxicological profile. Plants showed no antibacterial activity against test isolates. Significant antioxidant activity was demonstrated by the methanol extracts. Only C. quadrangularis was devoid of toxic action in the cytotoxicity assay. (14)
    Antispasmodic / Leaves: Study evaluated the antispasmodic activity of leaves by contractile activity on guinea pig ileum. Results showed the hexane extract possessed antispasmodic activity. (15)
    Cytotoxic Effects: Study evaluated 16 Bangladesh medicinal plants for cytotoxic effects against various human cancer cell lines (gastric, colon and breast). The methanolic extract of Blumea lacera showed the highest cytotoxicity against all tested cell lines. (16)
    Anti-Inflammatory / Anti-Bradykinin Activity: Study evaluated alcoholic extract of B. lacera on acute and chronic models of inflammation. Results showed significant anti-inflammatory effect against bradykinin induced edema, significant effect against carrageenan induced edema, and significant effect against granuloma pouch and cotton pellet implantation, although less potent than phenylbutazone and betamethasone. The anti-bradykinin activity may be responsible for its anti-inflammatory activity. (17)
    Mosquito Repellent: Study evaluated the repellent activity of B. lacera against mosquito vector Anopheles stephensi and Culex quinquefasciatus, with DEET as positive control. Results showed a potential as an effective mosquito repellent, with the a direct relationship with extract concentration and repellent activity. (18)
    Mosquito Repellent: Study evaluated the antipyretic activity of a methanolic extract of B. lacera leaves on albino rats on a pyrexia induced Brewer's yeast model. Results showed an antipyretic effect at doses of 200 and 400 mg/kg. (19)
    Antimicrobial: Crude extract of B. lacera was evaluated for antimicrobial and cytotoxic properties. Phytochemical screening yielded alkaloids, tannins, steroids, gums, and reducing sugar. Petroleum ether and methanol extracts showed antimicrobial activity against two bacteria and a fungus. (20)
    • Pharmacologic Activities: Study evaluated a crude methanol extract of whole plant for antidiarrheal using castor oil-induced diarrhea in mice, antimicrobial activity by agar disc diffusion method, anxiolytic activity using hold board and open field tests,membrane stabilizing activity by hypotonic solution induced hemolysis of human RBCs, anti-atherothrombosis using standard streptokinase, and antidiabetic activity using in vitro a-amylase inhibitory activity. The crude extract showed dose-dependent antidiarrheal activity. Antimicrobial assay showed better activity against tested fungi compared to bacteria. The plant exhibited significant anxiolytic activity. In vitro anti-atherothrombosis test exhibited 46.71% clot lysis. Membrane stabilizing evaluation showed inhibition of heat-induced hemolysis of RBCs. Study also showed dose dependent digestion of carybohydrates by a-amylase inhibition. Results suggest potential for many pharmaceutical applications. (23)
    • Antiulcer Effects / Leaves: Study reports on the in vivo antiulcer activity of methanol extract of leaves of B. lacera  on Long-Evans rat and in silico studies on its bioactive constituents. Treatment with MEBLL markedly attenuated ulcer and protected the integrity of gastric mucosa by preventing mucosal ulceration altered biochemical parameters of gastric juice such as carbohydrate, total protein and pepsin activity. The experimental group significantly (p<0.001) inhibited gastric lesions and malondialdelhyde (MDA) and upregulated antioxidant enzyme levels.  Results showed MEBLL has ulcer healing property in both in vivo and in silico studies. (24)
    • Attenuation of Anxiety and Depression: Study evaluated the neuropharmacological of Me-BLL at doses of 200-400 mg/kg p.o. in Swiss albino mice. EPM (elevated plus maze) and LDB (light-dark box) tests showed increased time sent in open arms and light box. HBT (hole-board) test showed increased number of head dipping, indicating anxiolytic effects. TST (tail suspension test) and FST (forced swimming) tests showed decrease in immobility time suggesting antidepressant effect. Of the bioactive lead molecules, thymol and cuminol revealed potential anxiolytic and antioxidant effects, while stigmast-5-en-3.beta.-ol and gamma-sitosterol showed promising antidepressant effects. (25)
    • Antioxidant / Antimicrobial /  Leaves: Study evaluated the antioxidant and antimicrobial activities of various extracts of B. lacera leaves. The methanol extract significantly inhibited the DPPH radicals at concentration ranging from 1000-5000 µg/ml. The IC50 was less than standard ascorbic acid. The ethyl acetate leaf extract showed highest antibacterial activity against S. aureus, P. aeruginosa, S. typhi.(see constituents above) (26)
    • Cytotoxic Steroidal Glycoalkaloid / Apototic /  Leaves: Study reports on the isolation of a new steroidal glycoalkaloid (SGA) 1. Cytotoxic activity of 1 and seven SGA analogues and steroidal alkaloids (SAs) (ß-solamarine, α-solanine, ß-solamargine, α-solasonine, khasianine, solasodine, tomatidine HCl) were evaluated against  four human cancer (AGS, HT-29, MCF-7, and MDA-MB-231) cell lines. SGA1 was the most cytotoxic against a number of human cancer cell lines with IC50 of 2.62 µM against MCF-7 cells, with highest apoptotic potential (32% AV/PI) on MCF-7 cells. (28)
    • Liposomal Drug Delivery / Hepatoprotective /  Leaves: Study evaluated the hepatoprotective effects of B. lacera leaf extract and its effectiveness  as a liposomal preparation vs suspension against carbon tetrachloride induced liver damage. Results showed the liposomal formulation showed significantly better hepatoprotective effects. The protective effect against CCl4-induced liver injury was attributed to presence of components such as phytol, and also due to improved bioavailability and stability of the leaf extract. (29)
    • Antibacterial /  Leaves: Study showed an ethyl acetate fraction of B. lacera was active against gram positive Bacillus cereus. A methanol extract showed significant dose dependent increase in antibacterial activity against gram-negative, Serratia sp., Proteus mirabilis, Salmonella typhi and Vibrio cholera. (30)
    • Inflammatory Bowel Disease /  Essential Oil: B. lacera is used in the traditional treatment of IBD. GC-FID-MS identified essential oil constituents. The major compounds could be potential moieties for treatment of IBD in terms of targeting h5HTR3A. (see constituents above) (31)
    • Anti-Leukemic / Antiviral: In a study of hot water extracts of five Taiwanese medicinal plants were evaluated for in vitro anti-leukemic and antiviral activities. Blumea lacera exhibited broad mild to moderate anti-leukemic activity activity. It also suppressed the replication of HSV-1 and HSV-2, with IC50s below 100 µg/mL. It showed no cytotoxic effects at concentration that inhibited HSV infection. (32)
    • Anti-Pyretic / Antinociceptive / Neuropharmacological: Study evaluated the in vivo anti-pyretic, neuropharmacological activity, and acute toxicity effects of leaf extracts of B. lacera in Swiss albino mice. In-vivo antipyretic testing using brewer's yeast method showed significant reduction in temperature, with diclofenac as standard. In gastrointestinal motility test, results showed significant reduction of GI motility when compared to standard loperamide. In in vivo antinociceptive testing, statistically significant (p<0.001, p<0.02, p<0.05) results were found when compared to standard diclofenac. None of the extracts showed any significant in-vivo acute toxicity in mice. (34)
    • Antidiabetic: Study evaluated the antidiabetic activities of extracts of aerial parts of Blumea lacera in streptozotocin induced hyperglycemic rats. Results showed marked antidiabetic activity. The methanol extract at dose of 400 mg/kg showed significant dose dependent antidabetic effects without destruction and restored the structure of liver and pancreas of hyperglycemic rats. (35) Study of methanolic extract of B. lacera in alloxan-induced diabetic rats showed restoration of blood glucose to normal levels. (36)
    • Ulcerative Colitis: Study evaluated the protective potential of standardized hydroalcoholic extract of Blumea lacera in acetic acid-induced ulcerative colitis (UC). Pretreatment with doses of 100 and 200 mg/kg significantly ameliorated the acetic acid-induced colonic injury, which paralleled with biochemical and histopathological examinations. Of 15 selected bioactive compounds, 5-hydroxy-3methyl-3,6,7,4-tetramethoxy flavones, lachnophyllic acid and d-fenchone exhibited better drug likeness property with higher docking score. The protective effect may be due to the synergistic effect of identified bioactive compounds via inhibition of key targets of inflammation. (37)
    • Anticancer / Melanoma Cell Line / Antioxidant / Leaves: Study evaluated the anticancer and antioxidant properties of crude leaf extracts from B. lacera. Results showed antioxidant activity by various assays. Anticancer activity was showed by the anti-migratory effect of the extract against the melanoma cell line. (38)
    • Cytotoxic Diterpenoid Glycoside / Apoptotic Effect / MCF-7 Breast Cancer Cells / Leaves: Study isolated a new diterpenoid glycoside, 6E,10E, 14Z-(3S)-17-hydroxygeranyllinalool-17-O-ß-D-glucopyranosyl-(1 -->2)-[α-L-rhamnopyronosyl-(1-->6)-ß-D-glucopyranoside (1) along with known diterpenoid glycoside (2) and two known glycosides (3,4) from methanol extract of leaves. Compound 1 showed strong cytotoxic activity with lowest IC50 value of 8.3 µM against MCF-7 breast cancer cells. In apoptosis and cell cycle analysis, compound 1 showed strong apoptotic activity against MCF-7 cells (45.5%) after 24 hours, with  no arresting effect on any of cell cycle phases in MCF-7. (39)
    • Antibacterial Herbal Ointment Formulation: Study reports on an herbal formulation from leaves and evaluated its antibacterial activity. The ointment prepared from B. lacera passed all physical evaluation parameters. It showed good antimicrobial activity against gram negative and gram positive bacteria compared to standard gentamicin, with ZOI between 23-28 mm. Activity could be due to leaf phytoconstituents like alkaloids, flavonoids, tannins, and phenols. (40)
    • Anti-Inflammatory / Thrombolytic / Leaves: Study investigated the anti-inflammatory and thrombolytic properties of B. lacera  leaves by observing cell lysis inhibition and percent clot lysis. Aspirin and streptokinase were used as standard drugs for the two experiments. Results showed dose dependent hemolysis inhibition and good clot lysis activity. The extract yielded alkaloids, steroids, terpenoids, flavonoids, glycosides, tannins, and phenolic compounds. (41)
    • Hepatoprotective / Rifampicin Induced Hepatotoxicity / Leaves: Study evaluated the hepatoprotective  activity of 70% ethanol extract of Blumea lacera leaves against rifampicin-induced hepatotoxicity in rats. Phytochemical screening yielded flavonoids, tannins and saponins. Results showed normalization of biochemical indicators of hepatotoxicity after pretreatment of extract. Hepatoprotective properties were attributed to polyphenolic compounds present in the plant. (42)
    • Biocontrol of Whiteflies / Leaves: Study showed a 10% alcoholic leaf extract of B. lacera is a very effective bio-pesticide to control whiteflies on guava plant (Psidium guajava). It kills whiteflies and the repellent property last for more than 45 days. (43)
    • Indomethacin Induced Enterocolitis / Aerial Parts: Study evaluated the therapeutic efficacy of ethanolic extract of aerial parts of B. lacera against indomethacin-induced enterocolitis in male Wistar rats. Pretreatment with EEBL or sulphasalazine significantly attenuated the indomethacin-induced proximal ileal damage, elevated  serum LDH, tissue MPO, LPO and lower levels of TT, with correlated histopathological alterations. The protective action against indomethacin-induced enterocolitis in rats may be attributed to its antioxidant, anti-inflammatory, antimicrobial, and membrane-stabilizing properties. (44)
    • Antifungal Against Aspergillus Spp. / Leaves: Study evaluated various extracts of leaves for antifungal activity, Growth inhibition was determined using food poisoning method against different Aspergillus spp. The ethanol extract of leaves showed more antifungal activity than methanolic and distilled water extract. A. parasiticus was more sensitive, followed by A. niger. Aspergillus niger was more sensitive to the ME followed by A. parasiticus and A. flavus. A. parasiticus was resistant, while other Aspergillus spp. were sensitive to distilled water extract. (45)
    • Treatment in Chronic Renal Failure / Aerial Parts: Study evaluated aerial parts of Blumea lacera ethanol extract for preventive and treatment effects on a CRF model induced by adenine in mice. Phytochemical screening revealed major chemical components including flavonoids, alkaloids, saponin, tannins, sterols, carotenoids, polysaccharides, organic acids, and reduced sugars. The extract showed significant preventive as well as treatment effects on the chronic renal failure model in mice, reducing urea and creatinine concentrations in blood, along with improved anemic status in both preventive and treatment group. (46)

    Availability
    Wild-crafted.

Updated August 2022 / December 2018 / June 2014

PHOTOS / ILLUSTRATIONS
IMAGE SOURCE: Two images: Blumea lacera [Malay Blumea, False Ox Tongue / © www.NatureLoveYou.sg / Click on image to go to source page / NatureLoveYou
OTHER IMAGE SOURCE: Photograph: Flower close-up / Photo 941319: Blumea lacera / © Satish Nikam / some rights reserved / / CC by NC-SA / click on image to go to source page / Naturalist

Additional Sources and Suggested Readings
(1)
A Useful Weed Blumea lacera L. / Pankaj Oudhia / Botanical.com
(2)
Monoterpene glycoside and flavonoids from Blumea lacera
/ Consolacion Ragasa, Jeannie Wong and John Rideout / JOURNAL OF NATURAL MEDICINES, Vol 61, Number 4, 474-475 / DOI: 10.1007/s11418-007-0180-5
(3)
Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts / Shaikh Uddin, Darren Grice and Evelin Tiralongo / Evidence-Based Complementary and Alternative Medicine, Vol 2011 (2011) /
doi:10.1093/ecam/nep111
(4)
ANTIBACTERIAL ACTIVITY OF SOME INDIGENOUS MEDICINAL PLANTS / MJ Islam, S Barua, S Das et al / J.Soil.Nature. 2 (3):26-28 (December 2008)
(5)
Triterpenoid and prenylated phenol glycosides from Blumea lacera / Rashmi Agarwal, Rahul Singh et al /
Phytochemistry, Vol 38, Issue 4, March 1995, Pages 935-93 / doi:10.1016/0031-9422(94)00747-H
(6)
Blumea lacera / Medicinal Plants of Bangladesh
(7)
Kakronda / Common names / Flowers of India
(8)
Comprative Evaluation of Blumea lacera var lacera and Blumea eriantha DC for Mushroom Tyrosinase Inhibitory Activity / Singh Umesh Pratap and R. Parthasarathy / International Journal of Pharmacy and Drug Research. Volume 1, Number 1 (2012), pp. 1-8
(9)
Composition of the essential oil of Blumea lacera DC. (Asteraceae) leaves from Nigeria / I. Laakso1, T. Seppänen-Laakso, R. Hiltunen1, O. Ekundayo / Flavour and Fragrance Journal, Vol 4, Issue 2, pages 73–75, June 1989 / DOI: 10.1002/ffj.2730040208
(10)
Comparative antidiarrhoel activity of ethanolic extract of root of Blumea lacera var lacera and Blumea eriantha DC on experimental animals / Singh Umesh Pratap and R. Parthasarathy / JPBMS, 2012, 17 (16)
(11)
Evaluation of antibacterial, antioxidant and toxicological activity of crude extracts of Adiantum capillus-veneris, Blumea lacera, Cassia alata, and Cissus quadrangularis from Faridpur, Bangladesh / Halder, Luke Donald
(12)
Phytochemistryical & Anthelmintic Studies on Blumea Lacera / Aditya M Pattewar*, A.B. Dawalbaja, D.M. Gundale, P.B. Pawar, P.G. Kavtikwar, P.P. Yerawar, T.M. Pandharkar, V.A. Patawar / Indo Global Journal of Pharmaceutical Sciences, 2012; 2(4): 390-396
(13)
STUDY ON HYPOGLYCEMIC ACTIVITY OF METHANOLIC EXTRACT OF Blumea lacera (LOCAL NAME: BONOMULA) LEAVES ON SWISS ALBINO MICE / Mohammad Habibur Rahman, Zakirul Islam, Md. Faruk Miya, Mita Munshi, Afroza Rahman Nishi, S.M. Nur Alam, Md. Nazmul Hasan / Conference Paper / El XXII Congreso de la Sociedad Italo Latinoamericana de Etnomedicina "Hernán Arguedas Soto" fue patrocinado por:, At Puntarenas, Costarica, Volume: 1
(14)
Evaluation of antibacterial, antioxidant and toxicological activity of crude extracts of Adiantum capillus-veneris, Blumea lacera, Cassia alata, and Cissus quadrangularis from Faridpur, Bangladesh / Halder, Luke Donald / BRAC University Institutional Repository
(15)
ANTISPASMODIC STUDIES ON LEAF AND ROOT EXTRACT OF BLUMEA LACERA
/ DIXIT, ASHISH; TIWARI, PAWAN; PARASHER, DEEPESH; BHARGAVA, SARVESH / International Journal of Pharmacy & Pharmaceutical Sciences;Jan2014, Vol. 6 Issue 1, p116
(16)
Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts / Shaikh J. Uddin, I. Darren Grice, and Evelin Tiralongo* / Evid Based Complement Alternat Med. 2011; 2011: 578092. / doi: 10.1093/ecam/nep111
(17)
Studies on the Anti-Inflammatory Effect of Blumea Lacera in Rat / NAG, B. N., DUTTA, M. K. and SIKDAR. S.
(18)
Mosquito repellent action of Blumea lacera (Asteraceae) against Anopheles stephensi and Culex quinquefasciatus / S.P. Singh and P.K. Mittal / International Journal of Mosquito Research 2014; 1(1):  pp 10-13 / ISSN: 2348-5906
(19)
Antipyretic activity of Blumea lacera leaves in albino rats. / Verma, L. K.; Singh, A. K.; Pachade, V. R.; Koley, K. M.; Vadlamudi, V. P. / Exploratory Animal and Medical Research 2012 Vol. 2 No. 1 pp. 56-59
(20)
Evaluation of antimicrobial and cytotoxic activities of the mehanolic and petroleum ether extract of Blumea lacera Burm.f in Bangladesh / Khurshid Jahan, Sukalyan Kumar Kundu, Md. Abdul Bake / Journal of Pharmacognosy and Phytochemistry, 2014; 2 (6): pp 104-108
(21)
Phytochemical and pharmacognostical studies of Blumea lacera (Roxb.) DC. / Vijay Kumar Yadav, Raghuveer Irchhiaya, A. K. Ghosh /
International Journal of Green Pharmacy, Jan-Mar 2018; 12(1) Suppl: S140
(22)
Folk medicinal use of Blumea lacera (BURM. F.) DC. To cure threadworms / Amit Tomar / Journal of Medicinal Plants Studies, 2017; 5(2): pp 336-337
(23)
Pharmacological Activities of Blumea lacera (Burm. f) DC: A Medicinal Plant of Bangladesh / Abdul Khair, Mohammed Ibrahim, Qamrul Ahsan, Mohammad A Rashid / British Journal of Pharmaceutical Research, 2014; 4(13): pp 1677-1687 / DOI: 10.13140/2.1.3054.7206
(24)
Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat:  A combined experimental and chemico-biological interaction / Md. Amjad Hossen, A S M Ali Reza, Md. Atiar Rahman et al / Biomedicine & Pharmacotherapy, March 2021; Vol 135: 111211 /
DOI: 10.1016/j.biopha.2020.111211
(25)
Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer-aided model / Md. Amjad Hossen, ASM Ali Reza, et al / Food Science & Nutrition, 2021; 9(7): pp 3836-3851 /
DOI:  10.1002/fsn3.2362
(26)
Investigation on antioxidant, antimicrobial and phytochemical profile of Blumea lacera leaf 
/ Umesh Khandekar, Sachin Tippat, Rahul Ghongade / International Journal of Biological & Pharmaceutical Research, 2013; 4(11): pp 756-761 / / eISSN: 0976-3651 / pISSN: 2229-7480
(27)
Hypoglycemic activity of methanolic leaf extract of Blumea lacera in Swiss-albino mice
/ Md Nazmul Hasan, Mohammad Habibur Rahman, Renkai Guo, Akinori Hirashima / Asian Pacific Journal of Tropical Disease, March 2015; 5(3): pp 195-198 / DOI:  10.1016/S2222-1808(14)60652-6
(28)
A New Cytotoxic Steroidal Glycoalkaloids from the Methanol Extract of Blumea lacera Leaves / Raushanara Akter, Shaikh J Uddin, Joe Tiralongo, Darren Grice, Evelin Tiralongo / Journal of Pharmacy & Pharmaceutical Sciences, 2015; 18(4) / ISSN: 1482-1826
(29)
Liposomal Drug Delivery of Blumea lacera Leaf Extract: In-Vivo Hepatoprotective Effects / Mohammad Hossain Shariare, Nusrat Jahan Khan Pinky et al / Nanomaterials, 12(13) / DOI: 10.3390/nano12132262
(30)
Ethnobotany and antibacterial potentiality of Blumea lacera L. from Sundarban Mangrove forest of Bangladesh / Fakhruddin Ali Ahmed, Anisure Rahman, Sanzida Mubassara, Gazi Mosharof Hossain / Jahangirnagar University Journal of Biological Sciences, 2014; 3(2)
(31)
Identification of potentially bioactive compounds from Blumea lacera essential oil by gas chromatography-mass spectroscopy and molecular docking studies for targeting inflammatory bowel disease / Rajesh K Joshi, Sandeep R Pai, Hemavathy Nagarajan / Natural Product Research, 2021 /
DOI: 10.10180/14786419.2021.2025368
(32)
In vitro Anti-leukemic and Antiviral Activities of Traditionally Used Medicinal Plants in Taiwan / Lien-Chai Chiang, Chun-Ching Lin et al / The American Journal of Chinese Medicine 2004; 32(05): pp 695-704 /
DOI: 10.1142/50192415X04002284
(33)
Phytochemical investigation and spectral studies of isolated flavonoid from ethanolic extract of whole plant Blumea lacera D.C. / Pratiba Mishra, Raghuveer Irchhiaya, Sunil Kumar Mishra / Journal of Pharmacognosy and Phytochemistry, 2015; 4(2): pp 1-4
(34)
In-vivo anti-pyretic, anti-nociceptive, neuropharmacological activities and acute toxicity investigations of Blumea lacera / Farzana Akhter Fancy, Mohammad Shahriar, Md Reazul Islam, Mohiuddin Ahmed Bhuiyan / International Journal of Pharmacy and Pharmaceutical Sciences, 2015; 7(1) / ISSN: 0975-1491
(35)
Antidiabetic effect of extract of Blumea lacera DC. in streptozotocin-induced hyperglycemic rats / Diptirani Rath, Snigdha Rani Panigrahy, Laxmidhar Maharana et al / International Journal of Pharmacy and Pharmaceutical Sciences, 2017; 9(10) / ISSN: 0975-1491
(36)
Anti-diabetic activity of methanolic extract of Blumea lacera DC (Asteraceae) in alloxan-induced diabetic rats / Durre Shahwar, Naeem Ahmad et al / Asian Journal of Chemistry, 2011; 23(12): pp 5403-5406 /
ISSN: 0970-7077 / Rec No: 20113356784
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Blumea lacera DC. accelerates the healing of acetic acid-induced ulcerative colitis in rats by regulating oxidative stress and colonic inflammation: in-vivo and in silico molecular docking experiments / Ashish Adhikari, Santosh Basnet, Veeresh Prabhakar, Veerapur / Advances in Traditional Medicine, 2021; 21: pp 463-474 /
(38)
In vitro antioxidant and anticancer activity of Blumea lacera leaf extract / Archana Madadev Rao / Journal of Biotech Research, 2021; 12: pp 168-176 / ISSN: 1944-3285
(39)
A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle / Raushanara Akter, Evelin Tiralongo et al / Natural Product Research, 2016; 30(23) /
DOI: 10.1080/14786419.2016.1146887
(40)
Formulation and Evaluation of Herbal Ointment of Blumea lacera / Siddhi Chandak, Kundan Tiwari, Yogesh Ushir / American Journal of Pharmatech Research, soso; 10(03) / ISSN: 2249-3387
(41)
An In-Vitro Study to Investigate Anti-Inflammatory and Thrombolytic Activity of Methanolic Extract of Blumea lacera Leaves / Faria Tahsin, Thesis
(42)
Protective Effect of Blumea lacera in Rifampicin Induced Hepatotoxicity in Rats / S Shirode Devendra, L G P Ram Bindurani, Gaurav Jain, Ashwini Singh / Asian Pacific Science Library, 2021
(43)
Blumea lacera (Asteraceae): A Biocontrol of Whiteflies / D G Jagtap, S V Maske, S R Bhokare, M Y Bachulkar / Emerging Research Trends in Life Science
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Protective effect of Blumea lacera DC aerial parts in indomethacin-induced enterocolitis in rats / Santosh Basnet, Ashish Adhikari, Veerash Prabhakar Veerapur / Inflammopharmacology, 2015; 23: pp 355-363 /
DOI: 10.1007/s10787-015-0243-2
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Antifungal Activity of Various Extracts of Blumea lacera (Burm.f.) DC Against Different Aspergillus Species /  R M Kagne, Vijay C Jamdhade, B S Surwase / Online International Interdisciplinary Research Journal, Sept-Oct 2012; 2(5) / ISSN: 2249-9598
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Preventive and treatment effects of Blumea lacera extract on chronic renal failure (CRF) in a mouse model / Khanh Linh Trinh, Van Cuong Tran / Terra Science and Education / DOI: 10.36838/v2i1.3
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Blumea / Wikipedia
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Blumea lacera / Plants of the World Online

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