Family Acanthaceae
Diluario
Acanthus ilicifolius L.
HOLLY-LEAVED ACANTHUS


Diluariu is a common name shared by: (1) Diluario, Acanthus ilicifolius, and (2) Kachumba, Argemone mexicana

Other scientific names  Common names  
Acanthus doloariu Blanco  Daguari (Tag.)  Lagiuriu (P. Bis.)
Dilivaria ilicifolia Nees Daluari (Tag.) Laguiriu (P. Bis.)
  Diliwario (Tag.) Lagiu-lagiu
  Diluariu (Tag.) Santing (Sul.)
  Doloariu (Tag.) Takis-lakis (Tag.)
  Duduaria (Tag.) Tindoi (Tag.)
  Dulauari (Pamp.)   Tinlui (Tag.)
  Duluarin (Tag.)   Tinglui (Tag.)
  Duluariu (Tag.)  Tinglog (Tag.)
  Galura (Tag)   Titio (Bis.)
  Kasumba (Ilk.)  Sea holly (Engl.)
  Lagiu-lagiu (Tag.)  Holly-leaved Acanthus (Engl.)

Botany:
· An erect or ascending, slightly branched shrub, 0.5 to 1.5 m high, the stems round, greening with a pair of short, sharp spines at the base of each petiole.
· Leaves: rigid, coriaceous, green and shining, oblong to oblong-lanceolate, 9 to 14 cm long, sinuate-toothed, the teeth spinous, petioles 1 cm long or less.
· Flowers: about 4 cm long each, subtended by an ovate, green, closely appressed bracts 7 to 8 mm long and two similar but smaller bracteoles. Sepals green, 10 to 12 mm long, 4, outer two opposite, two inner ones smaller. Corolla tube 1 cm long, the lower lip pale-blue, spreading or recurved, about 3 cm long, 2.5 cm wide, pubescent within. Stamens 4, in two pairs, shorter than lip; filaments short, ovary 4-ovuled. Spikes terminal, dense or interrupted.
· Fruits: capsules, 2 to 2.5 cm long, 4-seeded.

Distribution
In low wet lands near the sea, subject to the influence of salt water, throughout the Philippines along tidal streams, swamps, mangrove, etc.

Parts utilized:
· Roots
· Gathered the year round.
· Rinse, section into slices, sun-dry.

Chemical constituents and properties
Cooling, mildly salt-tasting.
Antiphlogistic, anticontusion, expectorant.
Galactagogue, expectorant, carminative.
Powdered leaves yield soft resins and a fatty matters colored with chlorophyll.
Leaves considered emollient.
• Study yielded: acancifoliuside, a new coumaric acid derivative and six known compounds:acteoside, isoacteoside, acanthaminoside among others.

Uses
Folkloric
Decoction of 30-60 g of dried material used for acute and chronic hepatitis, swelling-enlargement of the liver and spleen, swelling and enlargement of the lymph nodes, gastralgia, asthma.
Decoction of rrots and leaves used for asthma; also, to aid expectoration.
Root boiled in milk used for leucorrhea.
Tender shoots and leaves used for snake bites.
Leaves are high in mucilage and used as emollient fomentation in rheumatism.
Young leaves used as an antidote for snake venom.
In Malaysia, leaves used for rheumatism, neuralgia, and poison arrow wounds.
In Thailand, decoction of whole plant used for kidney stones.
Ground fresh bark is used as antiseptic.
Decoction of leaves for pain and as blood purifier.
Other
Plant is used in the manufacture of soap.

Studies
Anti-Cancer: Study showed the aqueous leaf extract prevented hepatic DNA alterations and chromosomal damage in tumor-bearing mice. and lengthened survival. It suggests A. ilicifolius may be a potential chemoprotector against hepatic neoplasia.
Anticarcinogenic / Tumour Reducing: The study found AI extract to be effective against tumor progression and carcinogen induced skin papilloma in mice.
Antioxidant and hepatoprotective effect of Acanthus ilicifolius: An alcoholic extract of AI inhibited the formation of oxygen derived free radicals in vitro and reduced induced hepatotoxicity in rats.
Anti-osteoporotic: Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells: The study yielded a new coumaric acid derivative, acancifoliuside and six other known compounds. Tested on osteoblastic cells, it concludes that A. ilicifolius may help prevent osteoporosis.
Availability
Wild-crafted. 


Additional Sources and Suggested Readings
(1)
Sea Holly / Acanthus spp.
(2)
Indian Medicinal Plant Acanthus Ilicifolius May Combat Liver Cancer / BREAKTHROUGH DIGEST MEDICAL NEWS
(3)
Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice / doi:10.1016/S0378-8741(01)00347-6 / Journal of Ethnopharmacology Vol 79, Issue 1, February 2002, Pages 27-33
(4)
Antioxidant and hepatoprotective effect of Acanthus ilicifolius / doi:10.1016/S0367-326X(00)00300-2 / Fitoterapia Vol 72, Issue 3, March 2001, Pages 272-277
(5)
Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells / Archives Of Pharmacal Research 31(7), 823-829. (2008)



Additional Sources and Suggested Readings
(1)
Sea Holly / Acanthus spp.
http://www.naturia.per.sg/buloh/plants/sea_holly.htm
(2)
Indian Medicinal Plant Acanthus Ilicifolius May Combat Liver
http://www.medicalnewstoday.com/articles/94312.php
(3)
Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice
http://www.sciencedirect.com/science
(4)
Antioxidant and hepatoprotective effect of Acanthus ilicifolius
http://cat.inist.fr/?aModele=afficheN&cpsidt=945532
(5)
Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells
http://www.springerlink.com/content/jp846147221h8458/