is Greek derived: pyro meaning 'fire' and stege meaning 'covering.' names: Species name venusta means 'pleasing.'
Flame flower is a climbing shrub with
6 to 8 ribbed branchlets. Leaves are compound, with 2 or 3 leaflets, bearing
3-parted terminal tendrils. Leaflets are ovate, acuminate, up to 5 centimeters
long. Flowers are reddish orange, in terminal panicled cymes, up to
5 centimeters long with reflexed corolla lobes. Fruit is a capsule, up to 30
- Recently introduced.
- Grows well in the Baguio area.
- Native to Brazil and Paraguay.
- Phytochemical screening yielded terpenoids, alkaloids, tannins, steroids, and saponins.
- Phytochemical studies
yield chemical constituents from the roots: allantoin, beta-sitosterol,
3b-O-beta-D glupyranosylsitosterol and hesperidin.
- Considered antimicrobial, antioxidant, tonic, and vulnerary.
- Studies have shown antioxidant, anti-inflammatory, antinociceptive, anthelmintic, hyperpigmentant, antibacterial, antifungal properties.
• No recorded
folkloric use in the Philippines.
• In Iracambi,
used as a tonic and antidiarrheal.
• In Brazil, used
as general tonic; also for diarrhea, dysentery, leucoderma and vitiligo, and common diseases of the respiratory tract, such as bronchitis, flu, and cold.
of P venusta showed the presence of carotenoids, steroids, terpenoids
and anthraquinones in pet ether extract and flavonoids and tannins in
the methanolic extracts. Results showed antioxidant activity due to
the flavonoids and b-carotene, and a potential source of natural antioxidation. (1)
• Antioxidant / Flowers and Roots: Study evaluated the antioxidant potential of P. venusta using DPPH, ABTS, and FRAP assays. Results showed P. venusta is a natural source of antioxidants. The extracts of flowers and roots contained significant amounts of phytochemicals with antioxidative properties to serve as inhibitors or scavengers of free radicals. (4)
• ACE Inhibition: One of the
plant extracts studied for angiotensin-converting enzyme inhibition. (3)
• Attenuation of Behavior Changes Induced by Lipopolysaccharide: Extract of P. venusta attenuated the depressive-live and exploratory behaviors induced by lipopolysaccharide. Results support the usefulness of the plant in traditional therapies for disorders like flu and cold, that induce sickness behaviors. (5)
• Anti-Inflammatory / Antinociceptive / Flowers: Study of a hydroethanolic extract in Swiss mice demonstrated anti-inflammatory activity. PvHE reduced paw edema induced by carrageenan and inhibited leukocyte recruitment into the peritoneal cavity. Extracts showed antinociceptive activity in acetic acid-induced writhing and formalin tests. The anti-inflammatory actions were attributed to the presence of acacetin-7-O-B-glucopyranoside. (6)
• Antimicrobial / Wound Healing: Study of extract showed potent wound healing capacity as shown by wound contraction and increased tensile strength. Induction in cytokine production may be one of the mechanisms involved in the wound healing acceleration. A PvE also showed moderate antimicrobial activity against B subtilis, S epidermis, S pyogenes, S aureus, E coli, M luteus, P aeruginosa, C albicans among others. (7)
• Genotoxicity Evaluation: Study evaluated the genotoxic effect of extracts of P. venusta in mice using micronucleus (MN) and chromosone aberration (CA) tests. Pyrostegia venusta did not show genotoxicity activity. (10)
• Hyperpigmentant Activity for Vitiligo / Melanogenic / Flowers and Leaves: Study evaluated the melanogenic activity of hydroalcoholic extracts from leaves and flowers of P. venusta on B16F10 melanoma cells. Results showed both extracts stimulated B16F10 melanogenesis at very low concentrations. Findings support the folk medicine use of P. venusta on the treatment of hypopigmentation diseases, such as vitiligo. (11)
• Vitiligo Treatment / Leaves: Study evaluated the anti-inflammatory and hyperpigmented activities of hydroethanolic extract of leaves in Swiss mice model of vitiligo induced by croton oil and monobenzone. Only tropical treatment with HE extract of P. venusta altered melanin specific marker in hair follicles. Topical and oral administration of P. venusta showed significant anti-inflammatory and hyperpigmented effects demonstrated topical and systemic effects in two animal models. (12)
• Prevention of Dental Biofilm / Dental Caries: Study evaluated the antibacterial and biological activities of P. venusta in the treatment of dental caries and periodontal disease. Crude extracts, ethyl actetate, and n-butanol fractions showed antibacterial activity. The EA fraction showed the highest inhibition against adherence of S. mutans and C. albicans. Results suggest a potential for the prophylaxis and treatment of caries or periodontal disease. (13)
• Anthelmintic: Study of chloroform and methanol extracts of P. venusta showed anthelmintic activity against Pheretima posthuma. Piperazine citrate was used as standard reference. The chloroform extract showed more effective anthelmintic action compared to the methanol extract. (14)
• Antitumor Activity / Apoptosis Induction: Study investigated the antitumor activity of P. venusta extracts against melanoma. The cytotoxic activity and tumor induced cell death of heptane extract from P. venusta flowers was evaluated against murine melanoma B16F10-Nex2 cells in in-vivo and in-vitro models. Results showed components of the heptane extract, mainly octasane and triacontane, showed cytotoxic activity against murine melanoma cells in vitro and promising antitumor protection against subcutaneous melanoma in vivo. (15)
• Anticandidal / Antioxidant: Study of flower extracts for in vitro anticandidal and antioxidant activities yielded one flavonoid (quercetin-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside) and two phenylpropanoid glycosides (verbascoside and isoverbascoside). The extracts were evaluated against five Candida strains viz., C. albicans, C. krusei ATCC 6258, and clinical isolates strains of Candida sp: C albicans, C. krusei, C. tropicalis, C. parapsilosis and C. guilhermondii. Semi-purified fraction and verbascoside showed similar activity to amphotericin B. (16)
- Ornamental cultivation.