Dregea volubilis is a stout, smooth, hoary or mealy, woody vine. Leaves are ovate or somewhat rounded, 7.5 to 15 centimeters long, 5 to 10 centimeters wide, rather leathery, rounded or pointed at the base, and pointed at the tip. Cymes are axillary or interpetiolar, and umbel-like. Flowers are green, about 1 centimeters across. Follicles are usually double, broadly lanceolate, 7.5 to 10 centimeters long, turgid, longitudinally ribbed, and velvety until mature. Seeds are elliptic, concave, smooth, shining, sharp-edged, and crowned with very fine, white, silky hairs.
- In the Babuyan Islands( Camiguin), Lubang, Luzon (Rizal, Bontoc and Batangas Provinces), and Panay, in thickets at low altitudes.
- Also occurs in India to Java.
- The fresh pericarp freed from the seeds contain an active principle, called dregein.
- Phytochemical screening yielded alkaloids, anthocyanins, anthracene glycosides, catecholic compounds, coumarins, flavonoids, iridoids, saponins and volatile oils.
- Phytochemical analysis yielded triterpenoid glycosides and aglycones, called dregeosides and drevogenins.
- Emetic, expectorant, febrifuge.
Leaves, roots, juice.
- In Thailand, occasionally grown as a vegetable. Young shoot and inflorescence used in a curry with dried, smoked fish.
- Leaves used as application to boils and abscesses.
- Roots and tender stalks used as emetic and expectorant.
- Juice exuding from cut roots are inserted into the nose to cause sneezing.
- In South East Asia, used as antifebrile and emetic.
- Used to treat hematemesis, sore throat, carbuncles, eczema, asthma and as antidote for poison.
• Anti-Inflammatory / Analgesic / Anti-Lipid Peroxidative: Considered by some authors as a synonym for D. volubilis. Phytochemical study yielded glucosides and alkaloids in the roots, considered to produce significant antioxidant, anti-inflammatory and analgesic effects.
• Possible Hepatotoxicity: Study of mature leaves of Dregea volubilis on male Sprague-Dawley rats showed degenerative changes in hepatocytes, with elevations in key hepatic enzyme concentrations.
• Polyoxypregnane glycoside / Chondroprotective: Study yielded polyoxypregnane glycoside which was shown to have a potent chondroprotective activity and presents a potential compound for a new pharmacologic agent for the management of degenerative joint diseases.
• Fruit Toxicity Studies: Acute and sub-chronic toxicity study of Dregea volubilis fruit in mice demonstrated no noticeable toxicity.
• Antitumor: Study concludes that Dregea volubilis fruit exhibited remarkable antitumor activity against Erhlich ascites carcinoma in Swiss mice.
• Anti-Inflammatory: Study showed the methanolic extract of leaves of Dregea volubilis in a carrageenan-induced model of acute inflammation exhibited significant anti-inflammatory activity.
• Immunomodulatory: Study of an ethanol extract from the stem parts of Dregea volubilis exhibited potential in treating T cell-mediated diseases through facilitation of apoptosis of activated T cells.
• Antioxidant / Free Radical Scavenging / Fruits: Study evaluated the antioxidant potential of various extracts of fruits of Dregea volubilis using different assays. Extracts exhibited potent total antioxidant activity increasing with concentration.
• Immunomodulatory / Apoptosis of Activated T Cells / Drevogenin-D: Study evaluated the immunomodulatory activity of DV extract. DVE tended to stimulate nonactivated lymph node cells while suppressing already activated T cells by selectively facilitating apoptosis through a capsase-dependent pathway. Drevogenin-D, an aglycone isolated, prevented selenite-induced oxidative stress and calpain activation in cultured rat lens.