Family Moraceae
Hauili
Ficus hauili Blanco

HAUILI FIG TREE
Leng guo rong

Other scientific names Other names 
Ficus septica Burm. f. Abnug (C. Bis.,P. Bis.)
Ficus laccifera Blanco Auili (Tag.)  
Ficus leucopleura F. Vill. Diudiu (Ig.)
Ficus radiata F. Vill. Hauili (Tag.) 
Ficus leucantatoma Merr. Kauili (Tag.) 
Ficus philippinensis Bonard Labnog (P. Bis.) 
Ficus altimeraloo F. Vill. Labnong (Tag.) 
Ficus didymophylla Warb. Lagmut (P. Bis.) 
Ficus rapiformis Rolfe Lapting (Ilk.)
  Latayi (Bon.) 
  Liliau (Ibn.) 
  Lio-lio (Pamp.) 
  Liu-liu (Ting., If., Bon., Ilk,) 
  Raya-raya (Ilk.)
  Reya-reya (Ilk.) 
  Ria-ria (Ilk.) 
  Sio (Bik.)
  Tabung (Sul.) 
  Tuliao (Ibn.) 
  Yabnoi (Iv.)
  Leng guo rong (Chin.)
  Septic fig (Engl.)
  Hauli fig tree (Engl.)

Botany
Erect, small tree, growing 3-8 meters high, smooth, with hairy young shoots. Leaves are smooth, shining, oblong-ovate to elliptic-ovate, 10-20 cm long, with tips tapering to a sharp point, and the bases pointed. Receptacles are shortly peduncled, axillary, solitary, ridged or angled, 1.5 - 2 cm in diameter.

Distribution
In thickets, at low and medium altitudes, throughout the Philippines.

Part utilized
Root, leaves, latex.

Constituents and properties
• Phytochemical study isolated isoflavone ficusin A and ficusin B from the root bark.
source

Uses
Folkloric
· Decoction of roots as diuretic.
· Poultice of roots for boils.
· Fresh leaves are sudorific; bruised with oil, used for headaches.
· Externally, antirheumatic.
· Latex used for herpes.
· Used by the Ifugaos for diarrhea, cough, malaria and stomach problems.

Studies
• Phytochemicals / Cytotoxicity:
(1) Study yielded six known phenanthroindolizidine alkaloids, eight new alkaloids – ficuseptines B-D, 10R,13aR-tylophorine N-oxide, 10R,13aR-tylocrebrine N-oxide among others – from the methanol extract of stems of Ficus septica. Cytotoxicity of the new alkaloids were assessed in vitro using HONE-1 and NUGC cell lines. (2) Study yielded phenanthroindolizidine N-oxide, ficuseptine-A together with 18 known compounds from the leaves of FS. Some of the compounds exhibited strong cytotoxic activity against two human cancer cell lines.
• Mucarinic Receptor Activity: Malaysian study of 224 plant extracts from 50 plant families for muscarinic receptor binding activity showed the greatest inhibition, and with other extracts that exhibited significant muscarinic properties were suggested to be worthy of further investigation.
• Anti-inflammatory:
Study examined the molecular mechanisms for the anti-inflammatory activity of phenanthroindolizidine alklaoids isolated from the leaves of Ficus septica. Study suggests that it exerts its anti-inflammatory effects by inhibiting expression of the proinflammatory factors and related signaling pathways.


Availability
Wild-crafted.



Additional Sources and Suggested Readings
(1)
Phenanthroindolizidine Alkaloids from the Stems of Ficus septica / Amooru G. Damu, Ping-Chung Kuo et al / J. Nat. Prod., 2005, 68 (7), pp 1071–1075 DOI: 10.1021/np050095o
(2)
Muscarinic Receptor Activity of Some Malaysian Plant Species / L.Y. Chung, K.F. Yap, M.R. Mustafa, S.H. Goh and Z. Imiyabir / Summary Pharmaceutical Biology / 2005, Vol. 43, No. 8, Pages 672-682
(3)
Phenanthroindolizidine Alkaloids and Their Cytotoxicity from the Leaves of Ficus septica / Heterocycles / VOL.57;NO.12;PAGE.2401-2408(2002)
(4)
Anti-Inflammatory Mechanisms of Phenanthroindolizidine Alkaloids / Cheng-Wei Yang, Wei-Liang Chen, Pei-Lin Wu, Huan-Yi Tseng, and Shiow-Ju Lee / Mol Pharmacol 69:749-758, 2006 / DOI: 10.1124/mol.105.017764


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