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Family Sapindaceae
Kalayo
Lepisanthes rubiginosa (Roxb.) Leenh.
RUSTY SAPINDUS
Chi cai

Scientific names Common names
Erioglossum rubiginosum Roxb.                   Unresolved Aboi (P. Bis.)
Lepisanthes rubiginosa (Roxb.) Leenh. Balinaunau (P. Bis.)
Sapindus rubiginosa Roxb. Balit (C. Bis.)
  Barit (P. Bis.)
  Buli-buli (C. Bis., P. Bis.)
  Buri-buri (P. Bis.)
  Duka (Bis.)
  Kalangkañgin (Tagk.)
  Kalayo (Tag.)
  Kalimaiu (Tag.)
  Lagui (Ting.)
  Liñgarau (Tag.)
  Magasilad (Mbo.)
  Malasaging-puti (Tag.)
  Palatangan-a-malabaga (Ilk.)
  Tagurirong (P. Bis.)
  Togoriron (P. Bis.)
  Usau-usau (Sul.)
  Rusty sapindus (Engl.)
Erioglossum rubiginosum (Roxb.) Blume is an unresolved name. The Plant List
Lepisanthes rubiginosa (Roxb.) Leenh. is an accepted name The Plant List

Other vernacular names
BANGLADESH: Bara harina, Chagalnadi.
BENGALI: Kaakjaam.
CHINESE: Chi cai.
MALAY: Buoh terajang, Kalaju, Kelat layu, Ki layu, Kulayo, Mertajam, Terajang.
THAI: Chan ru, Huat kha, Huat lao, Kamcham, Kasam, Kamsam, Ma cham, Ma huat, Ma huta pa, Sam sam, Si hok noi.
VIETNAMESE: Cây kén kén, Nhãn dê, Nhãn rừng.

Botany
Kalayo is a shrub or small tree, with a compact, bushy crown. All parts are covered with hairs. Leaves are pinnate, 15 to 50 centimeters long, with 4 to 6 pairs of leaflets. Leaflets are narrowly elliptic, 7.5 to 18 centimeters long, 3 to 7 centimeters wide, and blunt on both ends. Flowers are very fragrant, white, about 5 millimeters wide, and arranged in small groups in upright panicles 12 to 30 centimeters long. Fruit is about 1 centimeter long and covered with fine hairs; in ripening it turns successfully yellow, orange, purple, and nearly black, and when ripe, with a thin, juicy, sweetish and slightly astringent pulp.

Distribution
- Common in forests at low and medium altitudes throughout the Philippines.
- Also occurs from northern India to Indo-China and Thailand, through Malaya to tropical Australia.

Constituents
- Study analyzed the essential oil from flowers and fruits. Major components of flower essential oil were nerolidol (34.8%), palmitic acid (13.2%), and farnesol (10.0%). Fruit essential oil yielded palmitic acid (66.1%), myristic acid (10.0%), and linolenic acid (5.5%). (See study below) (4)
- Methanolic fraction isolated a tetrasaccharide derivative of farnesol named rubiginoside along with known triterpenoid saponins. (5)
- Study of methanol extract of barks yielded alkaloids, flavonoids, phenols, saponins, and carbohydrates. Physiochemical evaluation showed moisture content of 8.07%, total ash value 18.00%, acid soluble ash value 21.00%, water soluble ash value 9.50^, alcohol soluble extractive value 1.00%, and water soluble extractive value of 0.50%. (see study below) (10)

Properties
- Roots are astringent.
- Roots and leaves considered febrifugal.
- Studies suggest anti-inflammatory, membrane stabilizing, antioxidant, anticancer, antimicrobial, CNS depressant, low cytotoxicity properties.

Parts used
Roots, leaves and seeds.

Uses

Edibility
- Fruit is edible, but for some, not a pleasant edibility.
- In Java, shoots are used as vegetable.
Folkloric
- Astringent roots are used as decoction for fevers.
- Malays apply a poultice of leaves and roots to the head during a fever and to the body for skin problems.
- In the Dutch Indies, leaves are used for poulticing.
- In Indonesia, young stems eaten to induce sleeping.
- In Bangladesh, leaf juice taken for fever.
- In
India, plant used for treatment of leprosy. (7)
- Decoction of seeds used for whooping cough.

Studies
Anti-Inflammatory / Membrane Stabilization:
Study evaluated a methanol extract of Erioglossum rubiginosum in experimentally induced inflammation in a human red blood cell (HRBC) membrane stabilization method. Results showed significantly inhibited hypotonic solution induced lysis of human RBC membrane. The membrane stabilizing action and inhibition of erythrocyte lysis may be the possible mechanism of anti-inflammatory action. (3)
Essential Oil of Fruits and Flowers / Antioxidant / Anticancer / Antimicrobial:
Study analyzed Erioglossum rubiginosum fruits and flowers for essential oil. (See constituents above). In a study for anticancer activity against three human cancer cell lines, only the flower essential oil showed anticancer activity against NCI-H187 (small cell lung cancer). Flower essential oil also showed antioxidant activity. Both flower and fruit essential oils showed strong antimicrobial activity against Tricophyton mentagrophytes and moderate activity against E. coli, S. aureus, Pseudomonas aeruginosa and Candida albicans. (4)
CNS Depressant Effect / Fruit:
Study of an aqueous extract of pericarp of fruits at intraperitoneal doses significant reduced spontaneous locomotor activity, increased thiopental-induced sleeping time and affinity toward dopaminergic receptors, inhibited apomorphine-induced climbing behavior in mice, and exhibited affinity toward D2 receptors, suggesting dopamine D2 antagonism. (8)
Antimicrobial / Low Cytotoxicity / Bark:
Study of methanol extract of bark showed significant antibacterial activity against gram-positive Staphylococcus aureus, gram-negative Salmonella typhi and Shigella dysenteriae and mild antifungal activity against Aspergillus niger and Candida albicans. Cytotoxicity evaluation by brine shrimp lethality bioassay showed very low cytotoxic property with LC50 value of 29.47 µg/ml compared to vincristine sulfate standard (0.451 µg/ml). (10)
Acetylcholinesterase Inhibitory Activity / Fruits:
In a study of six aqueous fruit extracts from 19 analyzed fruits for potential acetylcholinesterase inhibitors, A. sapota showed the highest AChE inhibitory activity (IC50 1.17 mg/ml) followed by L. rubiginosa, F. elephantum, T. bispinosa, Z. jujuba and P. peruviana. (11
)

Availability
Wild-crafted.

Godofredo U. Stuart Jr., M.D.

Last Updated March 2016

IMAGE SOURCE: / Photo / Lepisanthes rubiginosa / Leaves at Kahanu Gardens NTBG Kaeleku Hana, Maui - Credit: Forest and Kim Starr - Plants of Hawaii - Image licensed under a Creative Commons Attribution 3.0 License, permitting sharing and adaptation with attribution.) / Click on image to go to source page / alterVISTA

OTHER IMAGE SOURCE: / Photo / FRUITS / 'Gum Chum' in Thai, or Lepisanthes rubiginosa / © SWASH / Non-Commercial use / click on image to go see source page / The SWASH Times

Additional Sources and Suggested Readings
(1)
Lepisanthes rubiginosa (Roxb.) Leenh. (accepted name)
/ Chinese name / Catalogue of Life, China
(2)
Sorting Lepisanthes names / Authorised by Prof. Snow Barlow / Maintained by: Michel H. Porcher / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE / Copyright © 1997 - 2000 The University of Melbourne.
(3)
Membrane stabilization – A possible mechanism of action for the anti-inflammatory activity of a Bangladeshi medicinal plant: Erioglossum rubiginosum (Bara Harina)
/ Pankaj Chandra Debnath, Abhijit Das, Amirul Islam, Md. Ariful Islam, Md. Mahadi Hassan, Sultan Md. Gias Uddin / Pharmacognosy Journal, Volume 5, Issue 3 , Pages 104-107, May 2013
(4)
A comparative study of the essential oil from flowers and fruits of lepisanthes rubiginosa
/ Stephen G. Pyne,
Boonsom Liawruangrath, Saisunee Liawruangrath, A Teerawutkulrag, J Chuangbunyat / Acta Pharmaceutica Sciencia, 2011, 53 (4), 535-542.
(5)
Rubiginoside, a farnesyl glycoside from Lepisanthes rubiginosa. / Adesanya SA, Martin MT, Hill B, Dumontet V, Van Tri M, Sévenet T, Païs M. / Phytochemistry. 1999 Aug;51(8):1039-41.
(6)
ETHNO-MEDICO-BOTANICAL STUDY IN LAWACHARA NATIONAL PARK, BANGLADESH / MOHAMMAD ZASHIM UDDIN*, MD ABUL HASSAN, MIZANUR RAHMAN AND KAMRUL AREFIN / Bangladesh J. Bot. 41(1): 97-104, 2012 (June)
(7)
Anti-leprotic Plants of Chhattisgarh: A Review / M. Vinod, M. Sharma, A. kesharwani*, R. Thakur, H. Verma Rungta College of Pharmaceutical Science and Research, Kohka Road, kurud, Bhilai, C.G, India.
(8)
Effect of an extract of Erioglossum edule on the central nervous system. / Sattar M A, Gan EK, Loke SE, Mah KF, Wong WH. / J Ethnopharmacol 1989;25:217–220. / Ethnopharmacology of Medicinal Plants
Asia and the Pacific Christophe Wiart, PharmD
(9)
Lepisanthes rubiginosa (Roxb.) Leenh. / Synonyms / The Plant List
(10)
Pharmacological, Phytochemical and Physicochemical properties of methanol extracts of Erioglossum rubiginosum barks / Santanu Barua, S. M. Masud Rana*, Md. Mustahsan Billah, Zannatul Naim, Golam Sarwar
(11)
Acetylcholinesterase inhibitory potentiality of some minor fruits of West Bengal, India / Susmita Das, Bratati De / Journal of Pharmacy & BioAllied Sciences
It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page.

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