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Family Mimosoideae / Mimosaceae
Mimosa pudica Linn.

Pa chou cao

Scientific names Other common names
Mimosa hispidula Kunth Babain (Ilk.) 
Mimosa pudica Linn. Bain-bain (Ilk.)
Mimosa pudica var. pudica Damohia (Tag.)
  Dilgansusu (Ilk.)
  Harupai (S. L. Bis.)
  Huya-huya (Bis.)
  Kiromkirom (S. L. Bis.)
  Makahia (Pang., Tag.)
  Sipug-sipug (Sub.) 
  Tuyag-huyag (P. Bis.)
  Torog-torog (Bik.)
  Bashful mimosa (Engl.)
  Humble plant (Engl.)
  Sensitive plant (Engl.)
  Shame plant (Engl.)
  Tickle-Me plant (Engl.)
  Touch-me-not (Engl.)
Makahia is a common name shared by Mimosa pudica (bashful mimosa) and Biophytum sensitivum (Damong bingkalat, little tree plant).
Mimosa pudica L. is an accepted name The Plant List

Other vernacular names
ASSAMESE: Adamalati, Lajubilata.
BENGALI: Laajak, Lajjavathi, Lajjabati.
CHINESE: Pa chou cao, Zhi xiu cao, Hu he cao, Han xiu cao.
DANISH: Almindelig mimose.
DUTCH: Kruidje-roer-me-niet.
FINNISH: Tuntokasvi.
FRENCH: Mimeuse commune, Mimeuse pudique, Sensitive.
GERMAN: Gemeine Mimose, Sinnpflanze.
HINDI: Chuimui, Lajaalu, Lajjavanthi, Lajouni.
MALAYALAM: Tintarmani.
MARATHI: Lajalu.
SANSKRIT: Khadiraka, Lajjalu, Namaskaar, Namaskaari, Raktapaadi, Samangaa, Shamipatra.
SPANISH: Dormidera, Sensitiva, Vergonzosa.
TAMIL: Tottalavaadi.
TELUGU: Attaapatti.

Mimosa pudica derives from the Latin "pudica" meaning shy, bashful, or shrinking, with various other equally descriptive common names such as bashful mimosa, sensitive plant, sleepy plant, shy plant, touch-me-not, and humble plant.

Makahiya is a diffusely spreading, half-woody herb, with branched stems up to 1 meter long, sparingly prickly with numerous deflexed, bristly hairs. The leaves are very sensitive, both pinnae and leaflets, folding when touched. Pinnae are usually 4, digitately arranged at the end of each petiole, and 4 to 9 centimeters long. The leaflets are narrowly oblong, inequilateral, 1 to 1.5 centimeters long, sessile, sparingly bristly, with pointed tips. Heads are long-peduncled, solitary or 2 to 3 in each axil, about 1 centimeter in diameter. Pods are flat, slightly recurved, 1 to 2 centimeters long, with 3 to 5 one-sided joints that fall away on maturity. Florets are red in the upper part with pink to lavender filaments.

- Common weed widely distributed in the Philippines in open, moist, waste places, open grasslands and open thickets, at low and medium altitudes in settled areas.
- Introduced from tropical America.
- Pantropic weed.

- Seed contains a toxic alkaloid, mimosine, a non-protein alpha-amino acid, known to cause hair loss and depressed growth in mammals (an unlikely event in humans as this will require unusually large doses).
- Roots yield flavonoids, phytosterol, alkaloids, amino acids, tannins, glycoside, fatty acids.
- Leaf extract have yielded an adrenaline-like substance.
- Seeds contain a mucilage composed of d-xylose and d-glucoronic acid, yielding 17% greenish yellow fatty oil.
- Plant contains (1) tubulin with an ability to bind colchicene with its sulfhydryl groups. (2) crocetin dimethyl ester.

- Plant yields turgorine.
- Leaves and stems reported to contain the alkaloid mimosine; leaves yield mucilage; the roots yield tannins.
- Proximate composition showed a moisture content of 9.67% ±0.15, protein 8.37% ± 0.15, fat 1.43% ±0.01, ash 3.57% ±0.06, crude fiber 3.30%, carbohydrate 73.7%. Vitamin analysis yielded ascorbic acid 13.5 mg/100g, thiamine 0.60, riboflavin 1.10, and niacin 0.40. (48)
- Methanolic extract of leaves yielded terpenoids, flavonoids, glycosides, alkaloids, quinines, phenols, tannins, saponins, and coumarins. (60)

- Considered expectorant, anti asthmatic. analgesic, antispasmodic, alterant, sedative and antidepressant.
- Roots are bitter, astringent, acrid, alexipharmic, antispasmodic, aphrodisiac, constipating, cooling, diuretic, emetic, febrifuge, resolvent, vulnerary.
- Leaves are bitter, sudorific, tonic.
- Emetic effect attributed to mimosine.
- Studies have suggested antibacterial, antivenom, antifertility, antidepressant, anticonvulsant, and aphrodisiac, antimalarial, hepatoprotective, hypolipidemic, hypoglycemic, antinociceptive, nerve regenerative, antimenorrhagic, adaptogenic properties.

Leaflet movement physiology
The leaflets fold together in the early evening and reopens at sunrise. It is called bashful or sensitive because the leaflets fold together on touching, warming and shaking. The phenomenon is called seismonastic movement due to a rapid change in turgor pressure and changes in membrane permeability in the pulvini cells in the leaf regions with rapid movement of calcium ions. At night, the leaves also fold and bend, termed nyctonastic movements (reaction to absence of light).
When the leaflets fold together on touching, they reopen in about 10 minutes.
• Seismonastic Movement / Actin Cystoskeleton: Study showed fragmentation of actin filaments occurring during bending was involved in the regulation of movement. The effect of phosphatase inhibitors on the actin cytoskeleton affects dynamic reorganization of actin filaments and causes the seismonastic movement.

Parts utilized
Whole plant, leaves, roots.

- In the Philippines, roots used as diuretic; also used for dysentery and dysmenorrhea.
- Entire plant in decoction used as alterant and antiasthmatic.
- Root considered aphrodisiac, and used for bladder gravel and similar urinary complaints.
- Decoction or infusion of leaves used in asthma; expectorant.
- Used for hypertension, menorrhagia, glandular swelling, sore throat and hoarseness.
- Powdered seeds applied to wounds and sores.
- Bruised leaves applied to bruises.
- Decoction of leaves used for diabetes.
- Powdered roots and leaves taken with milk for piles and fistula.
- Juice applied externally to fistulous sores.
- Poultice of leaves for glandular swellings.
- Leaves and roots used for piles and fistula.
- Used as antifertility agent in some parts of India.
- 1:1 ethanol water extract used for pain relief.
- Seeds used a coffee substitute
- In China, used for treatment of anxiety and depression.
- In Ayurveda, used as antiasthmatic, aphrodisiac, analgesic and antidepressant; also used in diseases associated with corrupted bile and blood, bilious fever, piles, jaundice, leprosy, ulcers, and small pox.
- In India, used for birth control.
- In Ayurveda, root is used as vulnerary, and for the treatment of leprosy, dysentery, vaginal and uterine complaints, inflammation, asthma, fatigue, and blood diseases. In the Unani system, decoction of root is used as a gargle to reduce toothache.
- In the Antiles, Guiana, and La Reunion, roots used vomitive.
- In Indo-China, seeds used as emetic.
- In Mexico, used to alleviate depression.
- In Punjab and Cashmere, seeds used for sore throat.
- In Concan, paste of leaves applied to hydrocoeles and glandular swellings.
- Infusion of leaves used for dysentery; also as bitter tonic.
- Roots used for leucoderma, vaginopathy, metropathy, ulcers, dysentery, inflammations, jaundice, asthma, small pox, strangury, fevers.
- Leaves used for hydrocoele, hemorrhoids, fistula, scrofula, conjunctivitis, wounds and hemorrhages.
- Whole plants used for bladder calculi; externally, for edema, rheumatism, myalgia and uterine tumors.
- Whole plant, crushed, used for itching and scabies.
- In Malaysia, root decoction drunk as tonic; pounded leaves applied as poultice on body swellings.

• Antimicrobial: Study showed antimicrobial activity against Aspergillus fumigatus, Citrobacter divergens and Klebsiella pneumonia.
• Antimicrobial: Ethanolic extracts activity against B. subtilis, P. aeruginosa, K. pneumonia, A. flavus and T. rubrum. The antimicrobial activity was attributed to the presence of active constituents like alkaloids or tannins.
• Anticonvulsant: Study showed intraperitoneal use of Mimosa pudica decoction protected mice against pentylentetrazol and strychnine-induced seizures.
• Antifertility Effect / Roots: Studies on the root extract of M. pudica showed antifertility effect with prolongation of the estrous cycle and disturbance of the secretion of gonadotropin hormones in albino mice.
• Antitoxin / Sea Snake Venom: A study in India screened several herbal plants for antivenin activity against common sea snake venom Enhydrina schistosa, the most toxic among the common sea snakes. The investigation showed antivenom activity in the alcoholic extract of Mimosa pudica, Mucuna pruriens, and Andrographis paniculata.
• Antitoxin: Study on the aqueous extract of dried roots of Mimosa pudica showed significant inhibitory effect on Naja naja and Bangarus caerulus venoms.
• Antitoxin / Venom Neutralizing: Of 17 plants screened, only M pudica showed 100% ability in neutralizing venom lethality. Study showed the potential use of M pudica as an antivenom agent of plant origin against five poisonous snake venoms found in Malaysia.
• Two new C-glycosylflavones from Mimosa pudica: Two new C-glycosylflavones were isolated from the whole plant of Mimosa pudica, and their structures were determined as 6,7,3?,4?-tetrahydroxyl-8-C-[?-l-rhamnopyranosyl-(1 ? 2)]-?-d-glucopyranosyl flavone (1), 5,7,3?,4?-tetrahydroxy-8-C[?-d-apiose-(1 ? 4)]-?-d-glycopyranosyl flavone (2).
• Chromoblastomycosis: Study isolated Fonsecaea from the thorns of M pudica and suggests it could be a natural source of infection for the fungus Fonsecaea pedrosoi.
• Seed Mucilage / Sustained-Release Excipient: Study showed the dissolution profile from formulation containing mucilage to drug in the proportion of 1:40 was found to be similar to the commercial sustained-release formulation of diclofenac.
Anti-Depressant: Study suggests that M pudica produces antidepressant effect in rats with a profile similar to two tricyclic antidepressants.
Mimosine / Anti-Malarial: Mimosine found to be an iron chelator
acting on malarial bugs by preventing the replication of cells.
Apoptotic: Mimosine also causes apoptosis and studied for treating ovarian cancer and other highly vascularized tumors.
Anthelmintic: The Anthelmintic effect of Makahiya (Mimosa pudica) leaves Extract in Native Chicken (Gallus domesticus) naturally infected with Gastrointestinal Parasites (Thesis) (5)
Anti-Hepatotoxic / Antioxidant: Study showed the co-administration of Mimosa pudica aqueous extract significantly lowered the level of lipid peroxidation in alcohol-fed mice. (16)
Anti-Hyperglycemic: Mimosa pudica is one of eight medicinal plants in an Ayurvedic herbal formulation, Ilogen-Excel, showing antihyperglycemic effect in STZ-induced diabetic rats. (17)
Nerve-Regenerative: (1) Study showed Mimosa pudica extract possess nerve-regenerative potential in rats with sciatic nerve injury. (2) In rats with experimentally injured sciatic nerves, nerve regeneration was 30-40% higher in rats treated with M. pudica extract than the hydrocortisone treated group.
Antidiabetic Activity / Leaves: In a study of alloxan-induced diabetic rats, the ethanolic extract of Mimosa pudica leaves showed significant decrease of blood glucose level compared with Metformin as standard drug. (18)
Antioxidant / Antibacterial: Comparative antioxidant, antibacterial and general toxicity studies on extracts of two Bangladeshi medicinal plants, M pudica and M rubicau, showed both exhibited prominent antioxidant property. While M. rubicaulis did not show any antibacterial activity, M pudica displayed considerable bacteriostatic activity against all six bacterial strains tested - B cereus, B subtilis, E coli, ampicillin-resistant E coli, S aureus and P aeruginosa. (20)
Antinociceptive / Toxicity Studies: In an acute toxicity study, a single dose of aqueous extract of 2000 mg KBW showed no clinical signs of toxicity or mortality. Study also showed dose-dependent central and peripheral analgesic property. (22)
Hypolipidemic / Leaves: Study screened a chloroform extract for hypolipidemic activity in hyperlipidemia induced by an atherogenic diet in Wistar albino rats. Results showed significant hypolipidemic effect with lowering of the serum levels of biochemical parameters (lowering of TC, triglycerides, LDL,VLDL) with a significant rise in HDL, similar to standard drug atorvastatin. The extract showed significant protection of the atherogenic index against hyperlipidemia. Biologically active phytoconstituents such as flavonoids, glycosides, and alkaloids may be responsible for the hypolipidemic effect. (23)
Tannins / Antivenom: Study showed tannins obtained from M. pudica was better than tannic acid in neutralizing the lethality of N. kaouthia venom in vitro. Results suggest M. pudica has a potential for treating N. Kaouthia snakebites. (25)
Wound Healing / Roots
: (1) Study of the methanolic extract exhibited good wound healing activity, an effect attributable to phenol constituents. (2) Study of shoot and root extracts showed good wound healing activity when compared to standard drug Gentamicin. (3) In an incision wound model, topical application of chloroform and methanolic root extracts showed wound-healing activity with a significant rise in breaking strength, dry weight, and hydroxyproline content of the granulation tissue. (12)(28)(29)
Hepatoprotective / Carbon Tetrachloride Induced Toxicity: Study evaluated the hepatoprotective effect of a methanolic extract of leaves of M. pudica in carbon tetrachloride induced liver damage in wistar albino rats. Results showed significant hepatoprotective effect with lowering of biochemical parameters and confirming histopathological changes. Results were comparable to standard hepatoprotective drug Silymarin. Effects may be due to active phytoconstituents flavonoids, glycosides, and alkaloids. (31) The oral administration of crude powder of Mimosa pudica showed hepatoprotective activity of M. pudica on experimentally induced carbon tetrachloride hepatotoxic rats. (54)
Antiulcer: Evaluation in rats of extracts of M. pudica for anti-ulcer activity in ulcer models -- aspirin, alcohol, and pyloric ligation -- showed the alcoholic extract to significantly decrease the volume of gastric acid secretion, PH, free acidity and ulcer index. (32)
Homeophathic Mother Tinctures: Study showed significant differences in samples of mother tinctures. Alcohol content influenced the viscosity of tinctures.
Antioxidant Activity: Study evaluated the total flavonoid (TF) and total phenolic (TP) contents of ethanol extracts of whole plant, stem, leaf, and seed. Results showed the leaf extract with the highest amount of TF and TP, Results suggested Mp could be a potential rice source of natural antioxidants. (33)
Antioxidant: Study evaluated the in vitro antioxidant effect of an ethanolic extract of Mimosa pudica against free radical damage by different assay methods (DPPH, NO, ABTS, and H2O2). Results showed potent activity on Nitric Oxide and DPPH, compared to ascorbic acid and rutin as standards. (34)
Nootropic: Study evaluated nootropic effects in both acute and chronic models of amnesia induced by scopolamine and AlCl3. Results confirmed nootropic (cognition enhancement) activity of EEMP, attributed to flavonoids and its antioxidant property. (35)
Analgesic / Anti-Inflammatory: Study evaluated an ethanolic extract for analgesic and anti-inflammatory activity. Results showed potent antinociceptive action confirming the extract's central activity. In a carrageenan-induced paw edema model, results clearly demonstrated anti-inflammatory activity. (36)
Antitumor / Glycosylflavones: Six glycosylflavones isolated from Mimosa pudica were evaluated for antitumor activity. Results showed inhibition on the proliferation of three tumor cells studies, viz. MCF-7, JAR, and N-2 A. (37)
Cytotoxicity / Antioxidant: Various extracts of different plant parts (aerial parts and root) were screened for in vitro cytotoxicity, antioxidant, and antimicrobial activities. The methanolic crude extract of aerial parts showed moderate antioxidant activity. The petroleum ether and methanol crude extract showed potential cytotoxic activities by brine shrimp lethality assay. All crude extracts showed poor or no activity against test organisms. (38)
Mimosine Extraction: Mimosine, β-[N-(3-hydroxypyridone-4)]-α-aminopropionic acid, occurs in the shoots and stem of Mimosa pudica L. Study describes the extraction of mimosine using leaves, branches, and stems of sensitive plants aged about 4 months. Mimosine solution extracted by 70% ethanol solvent was condensed by releasing ethanol to make drinks. The product contains a variety of amino acids and minerals. (39)
Hypolipidemic / Butter Induced Hyperlipidemia: Study evaluated the hypolipidemic activity of M. pudica extract n high fat diet induced models of hyperlipidemia in rats. An ethanol extract showed significant hypolipidemic effects with decrease in TC, LDL, Triglycerides, and VLDL, and increase in HDL comparable to standard drug Lovastatin. (40)
Anti-Asthmatic / Roots: Study evaluated the antiasthmatic activity of aqueous extract of Mimosa pudica on in vitro and in vivo animal models. Results showed anti-asthmatic activity which could to attributed to bronchodilating, antihistaminic (H1-antagonist), mast cell stabilizing properties, suggesting potential in prophylaxis and management of asthma. (42)
Adaptogenic / Nootropic: Study evaluated the adaptogenic activity of an ethanolic extract of Mimosa pudica in chronic Alzheimer's model. Results showed significant improvement in memory, observed from test models, viz. morris water maze, radial arm maze. For adaptogenic testing, using Forced swim test, the EEMP showed significant reduction in swimming endurance time. Results suggest the EE at dose of 500 mg/kbw p.o. produces potential changes in chronic Alzheimer's model and stress. (43)
Suppressive Effects on LPS-Induced Pro-Inflammatory Mediators: Study isolated fourteen compounds from extract of whole plant. Some compounds were tested for anti-inflammatory effects, viz. ethyl gallate (3), gallic acid (10), caffeic acid (7), L-mimosine (12), jasmonic acid (11), crocin (14) and crocetin (4). The compounds showed anti-inflammatory effects in vivo and in vitro through reduction of LPS-induced pro-inflammatorry mediators. (44)
Pilot Clinical Studies Menorrhagia: 1986 Pilot clinical studies evaluated Mimosa pudica in women with excessive menstrual bleeding. Findings showed promise for further detailed trials in a larger sample size of patients with dysfunctional uterine bleeding. Tolerability of M. pudica was good. Result suggest conventional phase 1 studies with organ function tests, prior to embarking on large scale phase III studies. (45)
Anti-Inflammatory / Leaves: Study evaluated an ethanolic extract of M. pudica leaves using carrageenan induced paw edema and cotton pellet granuloma testing in albino rats. Results showed significant dose dependent anti-inflammatory effect in acute and chronic phases of inflammation. (46)
Antifungal: Study evaluated the antifungal activity of M. pudica extract against five potentially pathogenic microorganisms: Trichophyton mentagrophyte, T. verrocuson, Microsporum nanum, Aspergillus niger, and A. flavus. Antifungal activity against the isolates increased significantly with concentration. No activity was seen against Aspergillus niger. (47)
ß-Adrenoreceptor Mediated Relaxation of Myometrium: Study investigated the molecular mechanism of tocolytic activity of methanol extract of M. pudica seeds on isolated uterine strips of pregnant buffaloes. Results showed concentration dependent inhibitory effect on buffalo myometrium, probably through inhibitory ß-receptors. Calcium channels did not seem to regulate the tocolytic effect of the seeds extract. (50)
Antimalarial / Leaves: Study evaluated the ethanolic extract of leaves of P. niruri and Mimosa pudica for antimalarial activity against Plasmodium berghei infections in mice. The leaf extracts showed significant antiplasmodial activity in all three models of antimalarial evaluation. Phytochemical screening yielded antiplasmodial constituents such as terpenoids, flavonoids, and alkaloids. (53)
Anti-Inflammatory / Free Radical Scavenging: Study evaluated the in vitro free radical content and anti-inflammatory activity of Mimosa pudica using carrageenan-induced paw edema assay and cotton wool granuloma in rats. Results showed the ethanolic extract of MP possesses potent anti-inflammatory activity possibly due to its free radical scavenging properties. The reference drug was ascorbic acid. (54)
Analgesic / Antiepileptic / / Free Radical Scavenging: Study of ethyl acetate extract of leaves of Mimosa pudica on rodents showed potent dose dependent analgesic activity by hot plate, tail flick, and acetic acid-induced writhing in rats. Antiepileptic activity was evidenced by significant reduction in the duration of seizures induced by MES and delayed onset of tonic-clonic seizures produced by PTZ and INH. Decreased locomotor activity was assessed through actophotometer, rotarod test, and traction test in mice. (55)
Phytochemical Profiling / Bioactive Compounds: Study GC-MS study and phytochemical profiling yielded a number of bioactive phytocompounds such as glycerin, phytol, myo-inositol and squalene, all of which possess a wide range of proven therapeutic uses. (56)
Immunomodulatory / Free Radical Scavenging / Flavonoids: Flavonoid isolated from dried samples of M. pudica exhibited dose dependent enhancement of activity in DPPH and hydroxyl radical scavenging assays. The flavonoids also showed in vitro growth stimulatory effect on isolated normal lymphocytes. (57)
Diuretic: Study evaluated M. pudica for diuretic activity using the lipschitz test. Results showed significant diuretic activity at doses of 100 and 200 mg/kbw by increasing total urine volume and ion concentration of Na, K, and Cl. Furosemide was used as standard drug. (59)
Aphrodisiac / Roots: Study evaluated M. pudica ethanolic extract of roots for its effect on libido of sexually normal Swiss albino male mice. General libido and potency was compared with standard reference drug sildenafil citrate. Results showed a significant and sustained increase in the aphrodisiac activity of normal male mice, with increased libido and hormone levels of testosterone, without adverse effects. (61)
• Glucuronoxylan / Drug Release Formulation / Seeds: Glucuronoxylan, a polysaccharide extruded from the seeds of M. pudica, is used for drug release (delayed/targeted/sustained release) formulations due to its high swelling index. M. pudica (Singh et al 2009; Kumar & Kumar 2011; Ahuja et al 2013) (63)
• Mimosine: Mimosine, a ß-[N-(3-hydroxypyridone-4)]-
α-aminopropionic acid, occurs in the shoots and stem of Mimosa pudica. Mimosine is synthesized from 3,4-dhydropyridine and O-acetylserine through the action of an isoform of cystein synthase. Mimosine has various pharmacological properties i.e., antimicrobial, the ability to block the cell cycle before G1/S transition, inhibit cardiac fibrosis, prevent neuronal death. (39)
• Alternative Therapy for Urinary Tract Infections / Roots: Study evaluat3d the therapeutic effect of root extracts against urinary tract infections. Results suggest decocted roots of M. pudica is comparable in effect to commercial drug in the treatment of urinary tract infection. (64)
• Anxiolytic / Antidepressant: The review focuses on the anxiolytic and antidepressant properties of M. pudica. The anxiolytic activity of M. pudica could be explained by the present of some components in extracts that interact with benzodiazepine/GABAA receptors as agonists, or with 5-HT1A receptors as agonists, or with NMDA receptors as antagonists. (65)

• CNS Depressant / Antinociceptive / Aerial Parts: Study evaluated the CNS depressant (open field and hole cross test) and antinociceptive activity (acetic acid writhing test and formalin induced pain) of methanolic extract of aerial parts. In open-field and hole cross test, there was statistically significant (p<0.05) decrease in locomotor activity. There was significant (p<0.05) and dose dependent decrease in writhing effects in acetic acid and formalin induced inflammatory pain. (66)
• Analgesic / Antiepileptic / Leaves: Study evaluated the antiepileptic and analgesic properties and effect of leaves on motor activities on rodents. The ethyl acetate extract showed dose-dependent analgesic activity. There was also dose-dependent improvement in motor performance. Extract showed significant reduction (p<0.01 and p<0.001) reduction in duration of seizures induced by maximal electro shock (MES) and delayed duration of convulsion against seizure induces. (67)
• Diuretic / Laxative / Leaves: Study evaluated methanol extract of leaves for diuretic and laxative activities in wistar albino rats. Results showed significant diuretic as well as laxative activities in a dose dependent manner. Activities were comparable to furosemide and agar-agar. (68)
• Antifungal / Leaves: Study evaluated ethanol and aqueous extracts of M. pudica leaves against fungi isolated from razor bumps. Trichophyton verrucosum and T. soudanense showed the highest diameter of zone of inhibition. Antifungal activity of ethanol extracts showed to be more effective than aqueous extracts. (69)
• Diuretic / Roots: Study evaluated the diuretic activity of ethanolic extract of root in albino rats. Results showed significant diuretic activity as evidenced by increased urine volume and enhancement of elimination of sodium, potassium, and chloride. Results suggest a beneficial role in volume overload conditions. (70)
Hypoglycemic / Hypolipidemic: Study evaluated the hypoglycemic and hypolipidemic activities of 80% ethanol extract of whole plant of Mimosa pudica in STZ-induced diabetic rats. The extract significantly (p<0.05) decreased FBG in diabetic rats and decreased TC, TG, and LDL while increasing HDL in diabetic rats. (71)
• CNS Activities: Study evaluated the CNS effects of Mimosa pudica in mice. Results showed increase in locomotor activity in extract treated mice as evidenced by a significant increase in open arm entries. The decrease in time spend in closed arm reflects anxiolytic property. (73)
• Wound Healing Activity / Leaves: Study evaluated the wound healing of ethanol extract of leaves in rats using excision and burn wound models. Results showed 73% and 92% reduction in wound area compared to control of 28%. In excision model, there was faster epithelialization and higher wound contraction which increased with concentration. (74)
• Antibacterial / Leaves: Study evaluated the antibacterial activity of leaf extracts against human pathogens. Results showed strong inhibition of growth of Bacillus subtilis and Staphylococcus aureus, and no activity against Candida albicans. (75)
• Renewable Source of Green Energy: The increased interest in solar energy led to the development of innovative technologies such as the use of Mimosa pudica as a renewable source of green energy. The parts of the plant containing black silicon, a semiconductor, were isolated. When a cell concentrate is exposed to the sun, an equivalent amount of energy is absorbed, which will cause the concentrate to split water molecules and produce a current. Mimosa pudica presents a potential renewable green-energy alternative as solar fuel, with a source that is abundant and easily available, and a product that is replicable and sustainable. (76)
• Wound Healing / Whole Plant: Study evaluated the wound healing potential of ethanol extract of dried powder of whole plant on deep dermal excision wounds in mice. Results showed dose dependent increase in wound contraction along with reduction in mean wound healing time. Study suggests enhanced wound healing by increased synthesis of collagen, hexosamine and DNA as well as glutathione concentration and activities of catalase and superoxide dismutase enzymes, along with reduction of nitric oxide synthesis and lipid peroxidation. (77)

- Wild-crafted.
- Tinctures, powders, seeds, extracts in the cybermarket.

© Godofredo U. Stuart Jr., M.D.

Updated March 2018 / March 2017 / December 2015

Photos / Content © Godofredo Stuart / StuartXchange
OTHER IMAGE SOURCE / Seeds / Mimosa pudica L. - shameplant / Steve Hurst @ USDA-NRCS PLANTS Database / USDA
OTHER IMAGE SOURCE / Dataja:Mimosa pudica Blanco2.253-cropped.jpg / Public Domain / Flora de Filipinas / Franciso Manuel Blanco (OSA), 1880-1883 / Modifications by Carol Spears / Wikimedia Commons

Additional Sources and Suggested Readings
The Sensitive Plant - Mimosa Pudica
Effect of Mimosa pudica root extract on vaginal estrous and serum hormone for screening of antifertility activity in albino mice / M Ganguly et al / Contraception, Volume 76, Issue 6, Pages 482-485
Preliminary Screening of Herbal Plant Extracts for Anti-venom activity against Common Sea Snake (Enhydrina schistosa) Poisoning

Two new C-glycosylflavones from Mimosa pudica

The Anthelmintic effect of Makahiya (Mimosa pudica) leaves Extract in Native Chicken (Gallus domesticus)
naturally infected with Gastro-intestinal Parasites
/ Hadjula, Mukramel / Thesis
Phytochemical Screening and Antimicrobial Activity of the Plant Extracts of Mimosa pudica L. Against Selected Microbes / N Gandhiraja et al / Ethnobotanical Leaflets 13:618-24, 2009
Anticonvulsant activity of Mimosa pudica decoction / E Ngo Bum et al / Fitoterapia • Vol 75, Issues 3-4, June 2004, Pages 309-314 / doi:10.1016/j.fitote.2004.01.012

Effect of Lajjawanti (Mimosa Pudica) on Regeneration of Nerve / G.C. Prasad et al / Jur. Res. Ind. Med.10: 4, 1975 pp.37-44
Antitoxin activity of Mimosa pudica root extracts against Naja naja and Bangarus caerulus venoms
/ Subramani Meenatchisundara et al / Bangladesh J Pharmacol 2009; 4: 105-109
ISOLATION OF Fonsecaea pedrosoi FROM THORNS OF Mimosa pudica, A PROBABLE NATURALSOURCE OF CHROMOBLASTOMYCOSIS / Claudio Guedes SALGADO et al / Rev. Inst. Med. trop. S. Paulo46(1):33-36, January-February, 2004
Change in the Actin Cytoskeleton During Seismonastic Movement of Mimosa pudica / Nobuyuki Kanzawa et al / Plant and Cell Physiology, doi:10.1093/pcp/pcj022
Evaluation of wound healing activity of root of Mimosa pudica / Kokane D D et al / J Ethnopharmacol. 2009 Jul 15;124(2):311-5. Epub 2009 May 3
POTENTIAL OF MIMOSA PUDICA (MIMOSACEAE) AGAINST SNAKE ENVENOMATION / Vejayan J et al / Journal of Tropical Forest Science, Oct 2007
Evaluation of Mimosa pudica Seed Mucilage as Sustained-Release Excipient / Kuldeep Singh et al / AAPS PharmSciTech • DOI 10.1208/s12249-009-9307-1
Mimosa pudica may possess antidepressant actions in the rat / Molina Contreras et al / Phytomedicine. 1999 Nov;6(5):319-23

Antihepatotoxic and antioxidant defense potential of Mimosa pudica / Nazeema T.H. and Brindha V./ International Journal of Drug Discovery, ISSN: 0975–4423, Volume 1, Issue 2, 2009, pp-01-04
Antihyperglycaemic effect of 'Ilogen-Excel', an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus / S. Umamaheswari, P. S. Prince / Acta Pol Pharm, Vol. 64, No. 1. (b 2007), pp. 53-61.
ANTIDIABETIC ACTIVITY OF THE LEAVES OF MIMOSA PUDICA LINN IN ALBINO RATS / N G Sutar et al / Journal of Herbal Medicine and Toxicology 3 (1) 123-126 (2009)
PRELIMINARY PHARMACOGNOSTIC EVALUATIONS AND PHYTOCHEMICAL STUDIES ON ROOTS OF MIMOSA PUDICA (LAJVANTI) / Milind Pande, Anupam Pathak / International Journal of Pharmaceutical Sciences Review and Research, Volume 1, Issue 1, March – April 2010; Article 010

Comparative bioacitivtry studies on two Mimosa species / Samuel Genest, Conor Kerr, Ankit Shah et al / Bol. Latinoam. Caribe Plant. Med. Aromaticas Vol 7 (1) 2008.
Mimosa pudica / Sensitive Plant / Herbal Monograph / Himalaya Herbal Health Care
Antinociceptive Activity of Mimosa pudica Linn /
M Karthikeyan and M K Deepa / Iranian Journ of Pharma and Therapeutics, Jan 2010, Vol 9, No 1, 11-14
Hypolipidemic Activity of Chloroform Extract of Mimosa pudica Leaves / Rekha Rajendron and Ekambaram Krishnakumar / Avicenna Journal of Medical Biotechnology, Vol. 2, No. 4, October-December 2010
Phytochemical Screening and Antimicrobial Activity of the Plant Extracts of Mimosa pudica L. Against Selected Microbe / N Gandhiraja, S Sriram et al / Ethnobotanical Leaflets 13:618-24, 2009.
Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom / Sia FY, Vejayan J, Jamuna A, Ambu S / The Journal of Venomous Animals and Toxins including Tropical Diseases, 2011, Vol 17, No 1, Pp 42-48
Sorting Mimosa names / Maintained by: Michel H. Porcher, / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE
Mimosa pudica / Catalogue of Life, China
WOUND HEALING ACTIVITY OF MIMOSA PUDICA LINN FORMULATION / S. Kannan , S. Aravinth Vijay Jesuraj, Sam Jeeva Kumar, K. Saminathan et al /
International Journal of PharmTech Research, Vol.1, No.4, pp 1554-1558, Oct-Dec 2009
Wound healing evaluation of chloroform and methanolic extracts of mimosa pudica roots in rats
/ Jejo Paul, Saifulla Khan, Syed Mohammed, Basheeruddin Asdaq / Int J Biol Med Res. 2010; 1(4): 223-227
Phytochemical Analysis and Anti Microbial Activity of Mimosa pudica Linn. / Tamilarsi T and Ananthi T / Research Journal of Chemical Sciences, Vol. 2(2), 72-74, Feb. (2012
Hepatoprotective activity of Mimosa pudica leaves against Carbon tetrachloride induced toxicity /
Rekha Rajendran, S. Hemalatha, K. Akasakalai, C.H. MadhuKrishna, Bavan Sohil, Vittal and R. Meenakshi Sundaram / Rekha Rajendran, et. al., /Journal of Natural Products, Vol. 2(2009):116-122
Anti-ulcer activity of Mimosa pudica leaves against gastric ulcer in rats / G.Vinothapooshan and K.Sundar /
Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1(4), October – December 2010
Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China / Jing Zhang, Ke Yuan, Wen-long Zhou, Jian Zhou, Ping Yang / Phcog Mag 2011;7:35-9
In Vitro Antioxidant Evaluation of Mimosa pudica / P. Muthukumaran*, P. Shanmuganathan and C. Malathi / Asian J. Pharm. Res. 2011; Vol. 1: Issue 2, Pg 44-46
Nootropic Studies of Ethanolic Extract of Mimosa pudica Linn. in Albino Wistar Rats / Sibi P Ittiyavirah & Delphia P George / American Journal of Phytomedicine and Clinical Therapeutics
Studies on antitumor activities of six glycosylflavones from Mimosa pudica / Jian-xin Zhu ; Huai-xia Yang ; Ke Yuan / Yu-xian Li ; Coll. of Pharmacy, Henan Univ. of Traditional Chinese Med., Zhengzhou, China
Cytotoxicity, Antimicrobial and Antioxidant Studies of the Different Plant Parts of Mimosa Pudica / Sadia Afreen Chowdhury, Jannatul Islam, Md Mahfujur Rahaman, Md Mostafizur Rahman, Nowshin Nowaz Rumzhum, Rebeka Sultana, Most. Nazma Parvin / S. J. Pharm. Sci.1(1&2): 80-84/doi:10.3329/sjps.v1i1.1813
Hypolipidemic activity of Mimosa pudica Linn on Butter Induced Hyperlipidemia in Rats
/ A. Sowmya and T. Ananthi* / Asian J. Res. Pharm. Sci. 2011; Vol. 1: Issue 4, Pg 123-126
Studies of Antiasthmatic Activity of Aqueous Extract of Roots of Mimosa pudica Linn / Mali Prabha R, Patil Chandrashekhar D., Rahila Sheikh, Mali Pratibha R, Karigar Asif / International Research Journal of Pharmacy 2(1) 2011: Pp 104-110.
Adaptogenic and nootropic activity of Mimosa pudica in albino wistar rats / Sibi Perumbamkudiyil Ittiyavirah, Ibrahim Pullochal / International Journal of Nutrition, Pharmacology, Neurological Diseases, 2014, Vol 4, No 4, pp 231-236.
Anti-inflammatory Activity of Mimosa pudica Linn. (Mimosaceae) Leaves : An Ethnpharmacological study
Sunil Mistry*, R. Patidar, V.Vyas, J.Jena and K.R.Dutt / J. Pharm. Sci. & Res. Vol.4(3), 2012, 1789-1791
Antifungal screening of Mimosa pudica plant extracts against phytopathogenic fungi / I. Ibrahim D., I. Muhammad, A. I. Kanoma, K. Shehu, A. A. Aliero, R. U. Aliyu / Open Science Journal of Bioscience and Bioengineering, 2014; 1(1): 1-12
Proximate Composition and Vitamin Levels of Seven Medicinal Plants / Olayiwola Olajumoke Abidemi / International Journal of Engineering Science Invention, Volume 2 Issue 5 ǁ May. 2013 ǁ PP.47-50
The Use of Medicinal Plant Species by the Temuan Tribe of Ayer Hitam Forest, Selangor, Peninsular Malaysia / FARIDAH HANUM and NURULHUDA HAMZAH / PertanikaJ. Trap. Agric. Sci. 22(2): 85 - 94 (1999)
Mimosa pudica Seeds Produce β-adrenoceptor Mediated Relaxation of Buffalo Myometrium
/ R. Rathore, A. Rahal, R. Mandil and A. Prakash / Asian Journal of Animal and Veterinary Advances, 9: 355-361, 2014.
Mimosa pudica L. (Laajvanti): An overview / Hafsa Ahmad, Sakshi Sehgal, Anurag Mishra, and Rajiv Gupta / Pharmacogn Rev. 2012 Jul-Dec; 6(12): 115–124. / doi: 10.4103/0973-7847.99945
Pharmacology and Traditional Uses of Mimosa pudica / Baby Joseph*, Jency George, Jeevitha Mohan / International Journal of Pharmaceutical Sciences and Drug Research 2013; 5(2): 41-44
Antimalarial activity and phytochemical screening of ethanolic leaf extract of Phyllanthus niruri and Mimosa pudica / N. Aarthi, Kadarkarai Murugan / IJPRD 01/2011; 3(3).
Anti-Inflammatory and Anti-Oxidant Study of Ethanolic Extract of Mimosa pudica / Shofiul Azam*, Archi Farhana Huda, Kishower Shams, Prawej Ansari, Mustafa Khalid Mohamed, Md Mahmudul Hassan, Abul Kalam Azad, Kallol Kanti Mondal, and Shakil Mahmood Zaouad / Journal of Young Pharmacists, 2015
Analgesic, antiepileptic, and behavioral study of Mimosa pudica (Linn.) on experimental rodents
/ Ganesh Patro, Subrat Kumar Bhattamisra, Bijay Kumar Mohanty / International Journal of Nutrition, Pharmacology, Neurological Diseases, 2015, Volume 5, Issue 4, Pp144-150.
GC-MS study and phytochemical profiling of Mimosa pudica Linn / Sridharan, Sriram; Vaidyanathan, Meenaa; Venkatesh, Kavitha; Nayagam, Agnel Arul John / Journal of Pharmacy Research ; March 2011, Vol. 4 Issue 3, p 741
PHARMACEUTICAL SCIENCES AND RESEARCH (2012) / DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4254-61
Boolean function applied to Mimosa pudica movements / Thiago Paes de Barros De luccia* & Pedro Friedman / Plant Signaling & Behavior, Volume 6, Issue 9, 2011, pp 1361-1364/ DOI:10.4161/psb.6.9.16445
Evaluation of Diuretic Activity of Different Extracts of Mimosa pudica Linn. / A.Baghel, D. S. Rathore, and V. Gupta / Pakistan Journal of Biological Sciences 16(20): 1223-1225, 2013 / DOI: 10.3923/pjbs.2013.1223.1225
Phytochemical Analysis and Uses of Mimosa pudica L. in Chhattisgarh / Sandhya Madan Mohan, Bhawana Pandey, Sunita G. Rao / IOSR Journal of Environmental Science, Toxicology and Food Technology, Sept 2015, PP 01-04
Aphrodisiac Activity of Roots of Mimosa pudica Linn. Ethanolic Extract in Mice / *Milind Pande, Anupam Pathak / International Journal of Pharmaceutical Sciences and Nanotechnology, Volume 2, Issue 1, April – June 2009
Mimosa pudica / Synonyms / The Plant List
Mimosa pudica L., a High-Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals / Gulzar Muhammad, Muhammad Ajaz Hussain, Ibrahim Jantan, Syed Nasir Abbas Bukhari / Comprehensive Reviews in Food Science and Food Safety / DOI: 10.1111/1541-4337.12184
Roots of Mimosa pudica Linn “Makahiya” as an alternative treatment against urinary tract infections / Winston D. Balag-ey & Leonora E. Ngilangil / NLR Journal, Volume 3 (2009)
Medicinal Value of Mimosa pudica as an Anxiolytic and Antidepressant: A Comprehensive Review / Zoya Shaikh, Samaresh Pal Roy, Pankti Patel, Kashmira Gohil / World Journal of Pharmacy and Pharmaceutical Sciences, Vol 5, Issue 3, pp 420-432
CNS Depressant and Antinociceptive Activities of the Aerial Parts of Mimosa pudica / Irfan Sajid, Bijan Kumar Karmaker, Zamiul Rashid, M. Mominul Islam and M. Ekramul Haque / European Journal of Applied Sciences 5 (4): 127-133, 2013 / DOI: 10.5829/idosi.ejas.2013.5.4.8192
Analgesic, antiepileptic, and behavioral study of Mimosa pudica (Linn.) on experimental rodents / Ganesh Patro, Subrat Kumar Bhattamisra, Bijay Kumar Mohanty / International Journal of Nutrition, Pharmacology, Neurological Diseases, 2015, Volume 5, Issue 4, Pp 144-150 / DOI: 10.4103/2231-0738.167502
Diuretic and laxative activities of methanol extract of Mimosa pudica L. leaves / Rajendran Rekha / International Journal of Phytomedicines and Related Industries, 2010, Vol 2, Issue 3 / DOI : 10.5958/j.0975-4261.2.3.038
Antifungal activity of Mimosa pudica leaves extracts against fungal isolates from razor bumps in Sokoto Metropolis, Nigeria / Muhammad M.T., AbdullahiK., ShehuK.and ShinkafiS.A. / Annals of Biological Sciences 2015, 3 (1):16-19
Diuretic Activity of Ethanolic Root Extract of Mimosa Pudica in Albino Rats / Kalabharathi HL, Shruthi SL, Vaibhavi PS, Pushpa VH, Satish AM, Mohammad Sibgatullah / Journal of Clinical and Diagnostic Research, 2015 Dec, Vol 9 (12) / DOI: 10.7860/JCDR/2015/14662.6877
 Hypoglycemic and Hypolipidemic Activities of Ethanolic Extract from Mimosa pudica L. in Normal and Streptozotocin-Induced Diabetic Rats. / Yupparach P, Konsue A. / Pharmacognosy Journal. 2017; 9(6): pp 834-837 / DOI:10.5530/pj.2017.6.130
Mechanosensitivity Below Ground: Touch-Sensitive Smell-Producing Roots in the "Shy Plant," Mimosa pudica L. / Rabi A. MusahAshton D LesiakMax J MaronRobert B CodyDavid EdwardsKristen L FowbleA John DaneMichael C Long /  Plant Physiology / DOI: https://doi.org/10.1104/pp.15.01705
STUDY OF THE CNS ACTIVITIES OF MIMOSA PUDICA Linn. IN ANIMAL MODEL / R. Naga Kishore*, A. Teja Sri, N. Anjaneyulu, Ch. Ramanikanth, A. Divya, K. Sainath and L. Saneela Suri / iajps,csk publications: 04 / http://doi.org/10.5281/zenodo.556379
Wound Healing Potential of Alcoholic Extract of Mimosa pudica Linn. Leaves / Manish Pal Singh*, S. Bharghava, R. S. Bhaduaria & C. S. Sharma / Pharmacologyonline 2: 32-38 (2010)
INHIBITORY ACTIVITY OF MAKAHIYA ( Mimosa pudica Linn ) LEAF EXTRACT TO THREE TEST ORGANISMS / Germana Gloria V. Molina / International Journal of Scientific & Engineering Research, Vol 6, Issue 12, Dec 2015
The Use of Weeds as a Source of Renewable Green Energy
/ Justus Nwaoga / The African Angle / World Policy
Mimosa pudica (Lajwanti) Accelerates Repair and Regeneration of Deep Dermal Excision Wound in Swiss Albino Mice / Ganesh Chandra Jagetia*, Rokin Lyngdoh, Lalramchuana and Bijoy Krishna Borah / International Journal of Complementary & Alternative Medicine, Vol 9, Issue 2 (2017) / DOI: 10.15406/ijcam.2017.09.00293

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