Pako- is a name shared by a number of Philippine medicinal plants:
(1) Pako - Athyrium eswculentum
(2) Pakong-alagdan - Blechnum orientale
(3) Pakong-anuanag, pako, buhok-virgin, dila-dila - Onychium siliculosum
(4) Pakong-gubat, pakong kalabao, Pityrogramma calomelanos
(5) Pakong-parang - Pteris mutilata
(6) Pakong-roman - Ceratopteris thalictroides.
(7) Pakong-tulog, pakong-cipres, Selaginella tamariscina
(8) Pakong buwaya - Cyathea contaminans

Family Selaginellaceae

Pakong tulog
Selaginella tamariscina
RESURRECTION FERN
Chuan Pai

Common Names
Kaim-kum (Ilk.) 
Kayumkom (Tag,)
Keoun Back (Korea) 
Pakaunkung (Ilk.)  
Pakong-sipres (Tag.) 
Pakong-tulog (Tag.)  
Chuan Pai (Chin.)
Resurrection fern (Engl.) 

Botany
Stems densely tufted, 4 to 15 cm long, branched nearly to the base; leaves of the lower plane crowded, ovate, with a distinct cusp, bright green, rigid, serrulate on both margins; the leaves of the upper plane are nearly as long, ovate lanceolate, cuspidate; the sporophylls are keeled.

Distribution and Preparation
• Cagayan, Ilocos Norte, Bontoc, Zambales, Pampanga, Rizal, Batangas, Laguna, Quezon.
• The whole plant may be collected throughout the year. Wash thoroughly, cut off the roots and sun-dry. This may also be processed into charcoal form by heating it with small glow until it turns black, sprinkle with some clean water and redry under the sun. Rhizome or the trunk-like portion of the main axis used for propagation. Preferably transplant collected living plants.

Properties and constituents
• Considered astrigent and hemostatic.

Uses
Nutrition
Edible: leaves; young shoots (cooked).

Folkloric
Hemoptysis, gastrointestinal hemorrhage, hematosuria, excessive menstrual flow.
Prolapse of the rectum: boil the drug material to a concentrated decoction and drink.
To stop external bleed of any cause: powder or dress the wound with granulated drug materials.
Selaginella plus Thuja: For hematochezia due to a boil in the anal region (patient cannot sit) or for an extra-menstrual bleeding uterus. Selaginella preparation plus Thuja leaf preparation: Grind into powder, add warm water. Drink the resulting infusion.
In China, used for trachiitis and tumors.
Other Uses in Asia
Called Keoun Back in Korea,
Selaginella tamariscina is a traditional medicinal plant for therapy of advanced cancer patients in the Orient. It is thought to modify gene expression and cytokine production. It also lowers blood sugar and lipid peroxide levels. The biflavones isolated from related Selaginella species exert both tumoricidal effects against human tumor cell lines and anti-mutagenic activity. There is ongoing study for its chemopreventive effects in stomach cancers.

Studies
• Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts.

Anti-mutagenic / tumoricidal: Called Keon in Korea, S tamariscina is a traditional medicinal plant for therapy of advanced cancer patients in the Orient. It is thought to modify gene expression and cytokine production. It also lowers blood sugar and lipid peroxide levels. The biflavones isolated from related Selaginella species exert both tumoricidal effects against human tumor cell lines and anti-mutagenic activity. There is ongoing study for its chemopreventive effects in stomach cancers.
Anti-fungal / Isocryptomerin / Amentoflavone:
(1) Study isolated isocryptomerin, a biflavoinoid, which exerted antifungal activity in an energy-independent manner without hemolytic effects. The antifungal activity may be through a membrane-disruption mechanism. (2) Study isolated amentoflavone from the ethyl acetate extract of the whole plant. It exhibited potent antifungal activity against several pathogenic fungal strains presenting a great potential to be a lead compound for the development of antifungal agents.
Antimetastatic:
Study demonstrated that Selaginella tamariscina extract could be a candidate antimetastatic agent against lung cancer.
Cell apoptosis: Cell apoptosis is important in cellular homesotasis and anticarcinogenesis. Study suggests oxidative stress may be involved in the cytotoxicity of ST and that ST-induced apoptosis of HL-60 cells is primarily mediated by the caspase activation pathway.
Vasorelaxation: Study yielded an active biflavonoid, amentoflavone and results suggest it relaxes smooth muscle via endothelium-dependent nitric oxide-cGMP signaling, with possible involvement of K and Ca channels.
Anti-gastric cancer: Study results suggest that Selaginella tamariscina could be a candidate chemopreventive agent against gastric cancer.
Candidiasis: S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina: Study suggests amentoflavone has a potential for treatment of candidiasis.

Chemical Constituents: Study isolated four compounds from the n-BuOH fraction of water extracts: tamariscinodise B, adenosine, guanosine and arbutin.
Anti-Allergic: Study of the ethanol extract of ST showed it could inhibit mouse systemic anaphylactic shock and dose-dependently block passive cutaneous anaphylaxis and skin reactions caused by exogenous histamine and serotonin. Results suggest EST inhibits mast cell-dependent, immediate allergic reactions and suggests ST and one of its active flavonoids present a potential remedy for allergy-related diseases.

Availability
Wild-crafted. 


Additional Sources and Suggested Readings
(1)
Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts
(2)
Isocryptomerin, a novel membrane-active antifungal compound from Selaginella tamariscina / Lee Juneyoung et al / Biochemical and biophysical research communications • 2009, vol. 379, no3, pp. 676-680 /
(3)
Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo / Shun Fa Yang et al / Journal of Ethnopharmacology Volume 110, Issue 3, 4 April 2007, Pages 483-489 / doi:10.1016/j.jep.2006.10.010
(4)
Selaginella tamariscina Induces Apoptosis via a Caspase-3-Mediated Mechanism in Human Promyelocytic Leukemia Cells / Seong-Hun Ahn et al / Journal of Medicinal Food • Summer 2006, 9(2): 138-144. doi:10.1089/jmf.2006.9.138.
(5)
Vasorelaxation by amentoflavone isolated from Selaginella tamariscina / Dae Gill Kang et al / lanta Med 2004; 70: 718-722 / DOI: 10.1055/s-2004-82720
(6)
Effects of Selaginella tamariscina on in vitro tumor cell growth, p53 expression, G1 arrest and in vivo gastric cell proliferation / I Lee / Cancer Letters, Volume 144, Issue 1, Pages 93-99
(7)
S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

(8)
Study on the chemical constituents of Selaginella tamariscina (Beauv.) Spring / Zheng X K et al / Yao Xue Xue Bao. 2004 Apr;39(4):266-8.

(9)
Antifungal effect of amentoflavone derived fromSelaginella tamariscina / Hyun Jun Jung et al / Archives of Pharmacal Research • Volume 29, Number 9 / September, 2006 / DOI 10.1007/BF02974074

(10)
Inhibitory Effects of Selaginella tamariscina on Immediate Allergic Reactions / Yue Dai / The American Journal of Chinese Medicine • Volume: 33, Issue: 6(2005) pp. 957-966 / DOI: 10.1142/S0192415X05003442


HOME      •      SEARCH      •      EMAIL