Family Rubiaceae
Rosal
Gardenia jasminoides
GARDENIA
Chih-tzu

Other scientific names  Common names 
Gardenia augusta Linn.  Rosal (Sp., Tag.) 
  Gardenia (Engl.) 
  Chih-tzu (Chin.)

Botany
· A glabrous, smooth branched shrub 1-2 m high.
· Leaves: opposite, elliptic-ovate, 2-6 cm long, narrowed and pointed at both ends, shining and short peticled. Stipulate.
· Flowers: large and very fragrant, occurring singly in the upper axil of the leaves. Calyx green, with funnel-shaped tube and about 1.5 cm long, 5-angled, or winged and divided into linear lobes about as long as the tube. Corolla usually double, white but soon turning yellowish and 5-8 cm wide. Stamens as many as the corolla lobes. Anthers linear, sessile. Ovary 1-celled, style stout, clavate, fusiform, or 2-cleft, ovules numerous on parietal placentae.
· Fruits: ovoid or ellipsoid, 2.5 to 4.5 cm long, 1.5 to 2 cm in diameter, yellow, with 5 to 9 longitudinal ridges. Maturing about the month of November.

Properties and constituents
• Antiophthalmic, emollient, emetic, stimulant, diuretic, antiperiodic, cathartic, anthelmintic, alterative, antispasmodic, antiseptic, febrifuge.
Study of chemical constituents in fruits isolated nine compounds: imperatorin, isoimperatorin, crocetin, 5-hydroxy-7,3',4',5'-tetrainethoxyflavone, 2-methyl-3,5-dihydroxychromone, sudan III, geniposide, crocin and crocin-3.

Distribution
A common garden plant. Only the double-flowered form occurs in the Philippines.

Parts utilized
· Parts utilized: roots, leaves, fruits.
· Collect fruits during August to October.
· Roots: rinse, section into pieces, sun-dry.
· Fruits: sun-dry after stemming.

Uses
Folkloric
· Decoction of leaves and flowers used for dyspepsia, flatulences, nervous disorders and abdominal pains.
· Decoction of bark (50-55 g) used for fevers. dysentery and abdominal pains.
· Decoction of flowers used as wash for inflammed eyes.
· Poultice of leaves for swollen breasts; may be mixed with vioileta and other herbs.
· Jaundice, hepatitis
· Fruit is antiseptic; used for tootaches, foul sores.
· Cough, fever.
· Bacillary dysentery.
· Nephritic edema
· Epistaxis, painful outgrowth at the tongue
· Mastitis, furuncle
· Lymph node tuberculosis
· Dosage: use 30 to 60 gms dried roots, 60 to 120 gms dried fruits in decoction. Fruits may be pulverized and applied to regions with furuncle, sprains, lymph node tuberculosis with water or alcohol.
• In China, extract used traditionally to treat diabetes.

In Oriental medicine, fruit has been used for inflammation, jaundice, headache, fever, liver disorders and hypertension.

Studies
Antioxidant: Crocin is a water soluble carotenoid found in the fruits of gardenia (Gardenia jasminoides) and seems to possess moderately strong antioxidant activity
Diabetes / Genipin: Study discovered "genipin" from the Gardenia extract. Genipin blocks the the UCP2 enzyme (uncoupling protein 2) that inhibits pancreatic insulin secretion. It suggests a potential for genipin-related compounds.

Antiangiogenic Activity: The n-butanol fraction of the ethanol extract of gardenia fruit was found to be most effective in the antiangiogenic assay.
Anti- Cerulein Pancreatitis Protective Activity: Study showed Gardenia jasminoides pretreatment ameliorated the severity of cerulein-induced acute pancreatitis in rats.
Alzheimer's Disease / Amyloid Beta Peptide: The brains of Alzheimer's disease patients have large depositis of amyloid beta peptide known to increase free radical production in nerve cells leading to cell death. The study of extract of G jasminoides suggest it can reduce the cytotoxicity of amyloid beta peptide in PC 12 cells, possibly by reducing oxidative stress.

Immunosuppressive Iridoids: Study yielded a new iridoid, gardaloside and a new safranal-type monoterpene, jasminoside G, with 10 other known compounds from the fruits of G jasminoides. Four of the compounds showed significant inhibition of IL-2 secretion and anti-CD28 monoclonal antibody co-stimulated activiation of human peripheral blood T cells.

Availability
Wild-crafted.
Common garden plant.
Cultivated for ornamental use.
 



Additional Sources and Suggested Readings
(1)
Antioxidant Properties of Crocin from Gardenia jasminoides Ellis and Study of the Reactions of Crocin with Linoleic Acid and Crocin with Oxygen / Thanh Quan Pham et al / J. Agric. Food Chem., 2000, 48 (5), pp 1455–1461 / DOI: 10.1021/jf991263j
(2)
Antioxidant potential of crocins and ethanol extracts of Gardenia jasminoides ELLIS and Crocus sativus L.: A relationship investigation between antioxidant activity and crocin contents / doi:10.1016/j.foodchem.2007.09.080
(3)
Gardenia fruit compound starting point for diabetes therapy
(4)
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced b cell dysfunction in isolated pancreatic islets. / Cell Metabolism 3, 417–427, June 2006 DOI 10.1016/j.cmet.2006.04.010 www.cellmetabolism.org
(5)
Antiangiogenic activity of Gardenia jasminoides fruit / Eun-Hee Park et al / Phytotherapy Research • Volume 17 Issue 8, Pages 961 - 962/ DOI 10.1002/ptr.1259
(6)
Gardenia jasminoides protects against cerulein-induced acute pancreatitis / Wok-Seok Jung et al
/ World J Gastroenterol 2008 October 28; 14(40): 6188-6194 / doi:10.3748/wjg.14.6188
(7)
Ameliorating Effect of Gardenia jasminoides Extract on Amyloid Beta Peptide-induced Neuronal Cell Deficit / Soo Jung Choi et al / Mol. Cells, Vol. 24, No. 1, pp. 113-118 /
(8)
Studies on chemical constituents in fruit of Gardenia jasminoides / Chen H et al / Zhongguo Zhong Yao Za Zhi. 2007 Jun;32(11):1041-3
(9)
Immunosuppressive Iridoids from the Fruits of Gardenia jasminoides / Wen-Liang Chang et al / J. Nat. Prod., 2005, 68 (11), pp 1683–1685 / DOI: 10.1021/np0580816/


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