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Family Liliaceae
Sabila
Aloe vera Linn.
ALOE
Lu hui

Scientific names  Common names
Aloe barbadensis Mill. Acibar (Span.)
Aloe elongata Murr. Dilang-boaia (Bik.) 
Aloe humilis Blanco Dilang buaya (Bik.) 
Aloe perfoliata Linn. Dilang-halo (Bis.) 
Aloe vera Linn.   Penca sabila (Spanish)  
Aloe vulgaris Lam. Sabila (Tag.) 
  Sabila pinya (Tag.) 
  Barbados aloe (Engl.)
  Aloe (English) 
  Aloe vera (English) 
  Burn plant (English) 
  Lu hui (Chin.) 

Other vernacular names
AFRIKAANS: Aalwee, Aalwyn.
BENGALI: Ghrita kumari, Kumari.
DANISH: Lægealoe.
DUTCH: Aloë.
FINNISH: Lääkeaaloe.
FRENCH: Aloès, Aloès vulgaire.
GERMAN: Echte Aloe.
HINDI: Guar patha, Ghikanvar.
ITALIAN: Aloe di Curacao, Aloe delle Barbados, Aloe mediterranea, Aloe vera, Legno aloe.
JAPANESE: Aroe.
KANNADA: Lolisara.
MALAY: Pohon gaharu.
MALAYALAM: Kumari.
MARATHI: Korphad.
NEPALESE: Ghiu kumari.
ORIYA: Kumari.
POLISH: Aloes zwyczajny.
PORTUGUESE: Aloés, Aloé vera, Babosa (Brazil), Aloés de Barbados, Erva-babosa, Azebre Vegetal.
RUSSIAN: Aloe, Aloe nastojaščee ,Aloe vera.
SANSKRIT: Ghirita kumari, Kumari.
SERBIAN: Aloja.
SHONA: Gavakava.
SPANISH: Acíbar, Aloe, Flor do deserto, Loto do deserto, Lináloe, Maguey morado, Penca sábila, Pitera amarelo, Sábila do penca, Sávila, Toots amarelo, Zábila, Zábila dos toots.
SWEDISH: Aloe, Barbados aloe.
TAMIL: Chirukuttali.
TELUGU: Chinna kalabanda.
THAI: Hang ta khe, Wan fai mai, Wan hang chora khe.
TURKISH: Ödağacı., Sarısabır, Sarýsabýr.
VIETNAMESE: Cây aloe vera, Cây Lô Hội , Cây Nha Đam.


Historical info
Aloe vera has been used by many cultures since ancient times. Early records of use appear in the 16th century BC Eber Papyrus. It was a component of the cosmetic beautifying regimes of Egyptian queens Nefertii and Cleopatra. It has been used in ancient wars for treatment of wounds. It held folkloric status as a herbal cure-all until the mid-1930s, when it found application in the treatment of chronic and severe radiation dermatitis. Today it is a component of countless beauty, health, and skin care products.

Botany
Sabila is an herb plant growing 30 to 40 centimeters high. Leaves arising from the ground are smooth, thick, fleshy, mucilaginous, succulent, 20 to 50 centimeters long, 5 to 8 centimeters wide, light green with white blotches, narrow-lanceolate, tapering, spiny-toothed margins. Flowering stalk is erect, usually twice the height of the plant. Flowers are 2 to 3 centimeters long, yellow, with segments that about equals the oblong tube.

Distribution
- Cultivated for ornamental and medicinal purposes.
- Introduced; a native of Africa.
- Occurs in subtemperate and tropical regions.

Production
- Commonly raised in clay pots or perforated containers.
- Sporadic in the yard; ordinary garden soil with compost is best.
- Regenerates its growth as lower leaves are cut, perpetuating availability of the material.

Properties
• Aromatic, astringent, aperient, purgative, emmenagogue, emollient, cholagogue, laxative, stomachic, tonic, vulnerary.
• Considered antitoxic, anticancer, antimutagenic.

Constituents
- Contains more than 75 active constituents: vitamins, enzymes, minerals, sugars, lignin, saponins, salicylic acids and amino acids.
- Aloin; barbaloin, 25%; isobarbaloin resin, 12.5%; (sicaloin; emodin; cinnamic acid; b-arabinose; oxidase); cinnamic acid; resin up to 20% (aloesin, aloesone, aloeresin A and C); coumarins, traces of volatile oil.
- Freeze-dried leaves of Aloe vera yielded aloe-emodin, feralolide, a mixture of aloins A and B, elgonica dimers A and B.

Parts utilized
Leaves, pulp, and sap.
Dried juice from leaves.
Harvest mature leaves and rinse with water; remove spines prior to use.

Uses
Edibility
Jelly from matured leaves can be cut in small cubes, boiled with rock sugar for a sweetened cooling drink.
Folkloric
- Use for dandruff.
- Juice of fleshy leaves is usually mixed with gogo by Filipino women and used to prevent falling of fair or as a cure for baldness.
- Juice from leaves mixed with wine used to preserve the hair
- In the Philippines, leaves used to poultice edema associated with beriberi.
- Juice from leaves mixed with milk used for dysentery and pains of the kidney.
- Fresh juice expressed from the leaves is spread on skin burns, scalds, scrapes, sunburn and wounds.
- Burns and scalds: Use ointment made by mixing equal amounts of powdered aloe and coconut oil.
- Used for wound healing.
- For conjunctivitis, leaf juice is applied to the outer eyelid.
- Used for sprains, sore throat.
- In small doses, used as a tonic; in larger doses, as aperient; and in still larger doses, drastically so; it is also used as emmenagogue and cholagogue.
- In small doses, considered stomachic tonic; in large doses, as purgative.
- In Costa Rica, the mucilaginous pulp of leaves is used as purgative.
- For contusions or local edema, bruised fresh leaves are applied as poultice over affected areas.
- For alopecia and falling hair, remove the spines, cut leaves and rub directly on the scalp. The juice of fresh leave may be mixed with gogo and used as a shampoo.
- Juice mixed with coconut milk used for dysentery and kidney pains.
- For bruises, equal parts of juice and alcohol are applied to affected areas.
- For hemorrhoids, cuticle from leaves used as suppository for hemorrhoids.
- In India and the Antilles the alcoholic tincture of inspissated juice is used for bruises, contusions and ecchymoses.
- In the Arabian peninsula, used for diabetes.
- For burns and scalds, an ointment is prepared by mixing 2 drams of powdered aloe with 2 drams.
- Also used for herpes simplex sores, tendinitis, dandruff, menstrual cramps, acne, stomatitis, varicose veins, warts, hemorrhoids.
- Used in combination with licorice roots to treat eczema and psoriasis.
New uses
- Benefits are derived from a combination of all active components; the aqueous form provides the most benefits.
- Leaf jelly used for various cosmetic and new-age concoctions for pimples, acne, stomatitis, hemorrhoidal itching, superficial burns. Aloe gel is a common household remedy for minor cuts, burns and sunburns.
- Salicylic acid content can inhibit prostaglandin and thromboxane formation by blocking the arachidonic acid cascade.
- UV-B protection through cinnamic acid.


Caution !
- Not for internal use.
- Some mineral cytotoxicity of the juice. Should be rinsed off after 30 minutes.

- Allergies: People with known allergy to other plants in the Liliaceae family (onions, garlic, tulips) may have allergic reactions to aloe. Delayed allergic reactions - hives and rash - may develop with prolonged use.

Studies
Laxative: (1) Aloin is the presumed laxative component of aloe. Further studies are needed to establish the dose and safety. (2) Anthraquinones in the latex considered to have potent laxative property, increasing intestinal water content, and stimulates mucus secretion and peristalsis.
Radioprotective / Gamma and UV Exposure: Studies have reported a protective effect against radiation damage to the skin. It decreases the production and release of skin keratinocyte-derived immunosuppressive cytokines (IL-10), preventing UV-suppression of delayed type hypersensitivity.
Genital Herpes: Two randomised, double blind trials compared topical aloe vera cream (0.5% hydrophilic) or placebo three times daily for two weeks in 180 men with a first episode of genital herpes; one also assessed topical aloe vera gel. Response rates in the two trials were almost identical. The proportions of patients cured in the two trials were 70% and 67% with aloe vera cream, 45% with aloe vera gel, and 7.5% and 7.0% with placebo. Times to healing were 4.8 and 4.9 days with aloe vera cream, 7.0 days with aloe vera gel, and 14 and 12 days with placebo.(24)
Psoriasis vulgaris: (1) Evidence suggests aloe extract in hydrophilic creams to be of benefit in psoriasis vulgaris. (2) One randomized double-blind trial assessed a 0.5% hydrophilic aloe vera cream compared with placebo cream in 60 patients with mild to moderate chronic plaque-type psoriasis over four weeks. The rate of cure was significantly better with aloe vera (83% ) than with placebo (7%) with no relapses. (24)
Dandruff: Studies suggest effectiveness for treatment of seborrheic dermatitis.
Antigenotoxic: Study showed antigenotoxic potentials of aloe and suggests a potential use in prevention of DNA damage caused by chemical agents. (2)
Psoriasis vulgaris: A double-blind placebo-controlled study to evaluate the efficacy and tolerability of topical Aloe vera in a hydrophilic creams showed it to be more effective than placebo without toxic or objective side effects and can be considered a safe alternative treatment for psoriasis. (3)

Anti-leukemic / Anti-Mutagenic:
Study isolated di(2-ethylhexyl)phthalate (DEHP) from Aloe vera. It exhibited growth inhibition against three leukemic cell lines and reduced AF-2-induced mutagenicity. DEHP was considered the active principle responsible for the anti-leukemic and anti-mutagenic effects in vitro. (4)
Acemannan / Macrophage Activation:
Study isolated a major carbohydrate fraction from the gel of Aloe vera leaf. It has been claimed to accelerate wound healing, immune stimulation and have anti-cancer and anti-viral effects. Study showed acemannan stimulate cytokine production, nitric oxide release. The production of cytokines IL-6 and TNF-alpha were acemannan dose-dependent. The results suggest acemannan may function, in part, through macrophage activation. (5)
Aloeride / Immunostimulatory Activity:
Study characterized a new immunostimulatory polysaccharide, Aloeride, from commercial aloe vera juice. (6)
Aloe-emodin / Anticancer / Antiproliferative:
Study showed aloe-emodin inhibited cell proliferation and induced apoptosis in two human liver cancer cell lines, but with different antiproliferative mechanisms. Results suggest aloe-emodin may be useful in liver cancer prevention. (7)
Biochemotherapy:
Study showed percentage of both objective tumor regressions and disease control was significantly higher in patients concomitantly treated with Aloe than with chemotherapy alone. Study suggest Aloe may be beneficial to use with chemotherapy to increase efficacy in terms of both tumor regression and survival time. (8)
Antidiabetic:
In a study of patients with non-insulin diabetes and Swiss albino mice with alloxan-induced diabetes, lowering of blood sugars was noted by as yet unknown mechanisms. (9)
Increased Glucose Tolerance:In a study of 5 plants used by Kuwaiti diabetics, only extracts with myrrh and Aloe gums effectively increase glucose tolerance in both normal and diabetic rats.

Burn Wound Healing:
Based on meta-analysis using duration of wound healing as the outcome measure, the healing time of the aloe vera group was 8.79 days shorted than the control group. Cumulative evidence supports aloe vera as beneficial intervention for burn wound healing in first to second degree burns. (Some studies have shown contrary results, with one showing delayed healing. Also, the use of aloe on surgical wounds has been reported to slow healing. (11)
Antimicrobial / Skin Infections:
Study evaluated the antibacterial activity of leaf and gel extracts against gram positive and gram negative skin infections isolates. The gel extracts showed antibacterial activity against both gram positive and gram negative isolates. Leaf extracts showed no activity. (16)
Photocarcinogenesis:
Aloe vera is incorporated in many skin care/cosmetic products. Studies have suggested it may enhance the induction of skin cancer by ultraviolet radiation. This study found a weak enhancing effect of aloe vera leaf or decolorized whole leaf on the photocarcinogenic activity of SSL (simulated solar light) in both male and female mice. (17)
Scabies:
In a study of 16 patients treated with Aloe vera and 14 patients with benzyl benzoate lotion, the Aloe vera gel showed to be as effective as benzyl benzoate in the treatment of scabies. (18)
Gastrointestinal Benefits:
Study showed oral supplementation with Aloe vera reduced postprandial bloating, reduced flatulence, and improved colonic bacterial function. (20)
Antiseptic:
Aloe vera yields six antiseptic constituents -- lupeol, salicylic acid, urea nitrogen, cinnamonic acid, phenols, and sulfur -- with inhibitory effect on fungi, bacteria and viruses. (22)
Antibacterial:
Study showed the possibility of presence of bioactive components in crude extracts. Tested against E. coli, B. subtilis, S. typhi, Pseudomonas, K. pneumonia, S. epidermis, a methanol extract showed maximum antibacterial activity as compared to other solvent extracts. (23)
Gastrointestinal Function in Normal Humans:
Study showed Aloe vera juice supplementation in normal individuals was well tolerated, without covert or overt adverse effects on GI physiology. There was improved bowel motility, increased stool specific gravity, and reduced protein putrefaction in the colon. There was reduced postprandial bloating and reduced flatulence. (25)
Oral Aloe vera for Treatment of Diabetes and Dyslipidemia:
Review suggests a preponderance of evidence that suggests a trend toward benefit from oral aloe vera in reducing FBS and HbA1c. There was triglyceride reduction, but evidence for LDL, HDL, and total cholesterol are conflicting. Weaknesses in study methods and inconsistency in data do not currently warrant recommendation of oral aloe vera for the management of diabetes mellitus or dyslipidemia. (26)
Antifungal:
Study on the antifungal activity of different extracts of Aloe vera plant showed the acetone extract as an effective antifungal to inhibit growth of Aspergillus flavus. (27)

Availability

- Wild-crafted.
- Cultivated.
- Ingredients to many commercial hair/cosmetic products.
- Gels, capsules, extracts in the cybermarket.


Last Update August 2014


Photos © Godofredo Stuart / StuartXchange

Additional Sources and Suggested Readings
(1)
Aloe (Aloe vera) / Drugs and Supplements
(2)
ANTI-GENOTOXIC EFFECT OF ALOE VERA GELR ON THE MUTAGENIC ACTION OF ETHYL METHANESULFONATE
Arch. Biol. Sci., Belgrade, 59 (3), 223-226, 2007. / DOI:10.2298/ABS0703223S
(3)
Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study
Tropical Medicine & International Health, Volume 1, Number 4, August 1996 , pp. 505-509
(4)
Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne / Lee K H et al / J Pharm Pharmacol. 2000 May;52(5):593-8.
(5)
Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel / Zhang L and Tizard IR / Immunopharmacology. 1996 Nov;35(2):119-28.
(6)
Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity / Pugh N et al / J Agric Food Chem. 2001 Feb;49(2):1030-4
(7)
The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines / Kuo P L et al / Life Sci. 2002 Sep 6;71(16):1879-92
(8)
A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer / Lissoni P et al / In Vivo. 2009 Jan-Feb;23(1):171-5
(9)
Studies On The Activity Of Individual Plants Of An Antidiabetic Plant Mixture / Al-Awadi FM and Gumaa KA / Acta Diabetol Lat Jan-Mar 1987, 24(1) p37-41
(10)
Antidiabetic Activity Of Aloes: Preliminary Clinical & Experimental Observations / Ghannam N et al / Horm Res 24(4):288-94 1986
(11)
The efficacy of aloe vera used for burn wound healing: A systematic review / R. Maenthaisong et al / Burns, Volume 33, Issue 6, Pages 713-718

(12)
Medicinal Plants - The Aloe Vera / Lee Song Cheong and Bro. Ooi Chooi Seng / Than Hsiang
(13)
Aloe / Overview / University of Maryland Medicinal Center
(14)
A prospective randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in chronic plaque psoriasis / Choonhakarn C, et al / ICD 2009
(15)
Aloe / Aloe vera / Mayo Clinic
(16)
Comparative study of antimicrobial activities of Aloe vera extracts and antibiotics against isolates from skin infections / Asma Bashir, Bushra Saeed, Talat .Y. Mujahid and Nayar Jehan / African Journal of Biotechnology Vol. 10(19), pp. 3835-3840, 9 May, 2011
(17)
Photocarcinogenesis study of aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 mice (simulated solar light and topical application study) / Natl Toxicol Program Tech Rep Ser. 2010 Sep;(553):7-33, 35-97, 99-103 passim.
(18)
Preliminary study of effectiveness of aloe vera in scabies treatment. / Oyelami OA, Onayemi A, Oyedeji OA, Adeyemi LA. / Phytother Res. 2009 Oct;23(10):1482-4.
(19)
Aloe Vera Juice and Gel Processing Study / US Farms, Inc.
(20)
Effect Of Orally Consumed Aloe Vera Juice On Gastrointestinal Function In Normal Humans / Excerpts By Jeffrey Bland, Ph.D. / Linus Pauling Institute of Science & Medicine Preventive Medicine, March/April 1985
(21)
Phytochemical study on Aloe vera / Jae-Sue Choi, Seung-Ki Lee, Chung-Ki Sung, Jee-Hyung Jung / Archives of Pharmacal Research, April 1996, Volume 19, Issue 2, pp 163-167
(22)
Aloe vera: A Short Review / Amar Surjushe, Resham Vasani, and D G Saple / Indian J Dermatol. 2008; 53(4): 163–166. / doi: 10.4103/0019-5154.44785
(23)
In-Vitro antibacterial activity of Aloe Barbadensis Miller (Aloe Vera) / Saba Irshad*, Muneeba Butt and Hira Younus / Intl. R. J. of Pharmaceuticals (2011), Vol. 01, Issue 02, pp. 59-64
(24)
Aloe vera: a systematic review of its clinical effectiveness./ Vogler BK, Ernst E. / British Journal of General Practice 1999;49:823-828
(25)
Effect Of Orally Consumed Aloe Vera Juice On Gastrointestinal Function In Normal Humans / Excerpts By Jeffrey Bland, Ph.D. / Linus Pauling Institute of Science & Medicine Preventive Medicine, March/April 1985
(26)
Oral Aloe Vera for Treatment of Diabetes Mellitus and Dyslipidemia / Minh Q. Ngo, Pharm.D., Nancy N. Nguyen, Pharm.D., Sachin A. Shah, Pharm.D. / Am J Health Syst Pharm. 2010;67(21):1804-1811.
(27)
Study on Effect of Aloe vera Leaf Extracts on Growth of Aspergillus flavus / A. Babaei*, M. Manafi2 and H. Tavafi / Annual Review & Research in Biology, ISSN: 2231-4776,Vol.: 3, Issue.: 4 (October-December)


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