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Family Meliaceae
Santol
Sandoricum koetjape Merr.

LOLLY FRUIT

Scientific names Common names
Melia koetjape Burm. f.  Santol (Tag.)
Trichilia nervosa Vahl Santor (Most dialects)
Sandoricum nervosum Katul (Sbl.)
Sandoricum indicum Cav. Kechapi (Eng.)
Sandoricum ternatum Blanco Red santol (Engl.)
Sandoricum koetjape Merr. Lolly fruit (Engl.)
  Wild mangosteen (Engl.)

Other vernacular names
FRENCH: faux mangoustan, Sandorique.
GERMAN: Sandoribaum.
MALAY: Sentul.
TAMIL: Sayai, Sevai.

Botany
Santol is a tree growing up to 20 meters high, with softly hairy young branches and leaves. Leaves are groups of 3 leaflets, elliptic to oblong-ovate, 10 to 25 centimeter long, with pointed tips and round bases. Flowers are numerous, somewhat fascicled, about 1 centimeter long, in greenish or yellowish clusters. Fruits are rounded and somewhat flattened, 4 to 6 centimeters, yellowish-orange when ripe with a thick pericarp. Seeds are large, surrounded by a translucent or pale, sweet tasting edible pulp.

 

Distribution
- Throughout settled areas in the Philippines, planted or semi-cultivated, and abundant in secondary forests.
- Introduced into the Philippines, now thoroughly established.
- Native to Malaysia, Cambodia and Southern Laos.
- Reported in Indonesia, India and the Andaman Islands.

Constituents
- Bark contains traces of a bitter principle, a toxic alkaloid.
- Seed contains an amorphous bitter principle.
- Bark also contains a bitter substance, sandoricum acid, similar to acids found in Chisocheton, dysoxylum, heynea and carapa.
- Thai study yielded two new limonoids from the leaves: sandoripin A and sandoripin B.
- Study on leaves have yielded trijugin-type limonoids, sandrapins A, B, C, D and E and sandoripin A and B.

- Studies have yielded more than 10 terpenoids.
- Seeds have yielded andirobin-type limonoids - sandoricin and 6-hydroxysandoricin.
- Fruit hulls have yielded bryononic acid and bryonolic acid terpenoids, meso-inositol and dimethyl mucate polyalcohol.
- Stem bark studies have yielded triterpenoids such as, katonic acid, indicic acid, koetjapic acid, 3-oxo-12-oleanen-29-oic acid, alloaromadendrene, caryophyllene oxide, spathulenol], bryononic acid, secobryononic acid, secoisobryononic acid, 20-epikoetjapic acid, 3-epikatonic acid and sandorinic acid A, B and C.

Properties
Roots is aromatic, carminative, antispasmodic, astringent, stomachic, and tonic.
Fruit considered astringent.

Parts used
Roots, bark, and leaves.

Uses
Nutrition / Edibility
- High in carbohydrates, fair in iron, but low in calcium.
- Fair source of vitamin B.
- Santol makes a delicious preserve - peeled, quartered, and cooked in syrup.

Folkloric
- Fresh leaves applied to the skin are sudorific.
- Used by the Ifugaos for diarrhea.
- Decoction or infusion of leaves used for baths to reduce fever.
- Also, used for diarrhea and as a tonic after childbirth.
- Bark poultice used for ringworm.
- Bitter roots, bruised with vinegar and water, is a carminative; used for diarrhea and dysentery.
- Pounded barks applied to ringworm.
- Leaves used for skin infections and rashes.
- Roots used as tonic.

- Roots used in Malayan medicine as preventive after childbirth and as a general tonic.
- In Malaysia, aqueous extract of the bark is consumed as a tonic after childbirth.
- In Indonesia, bark decoction used to treat leucorrhea and colic.

Studies
Ichthyotoxic and Anticarcinogenic Effects: Two ichthyotoxic triterpenoids were isolated with non-toxic katonic acid which showed remarkable inhibitory effect on Epstein-Barr virus early antigen activation. The triterpenoid koetjapic acid showed promising chemopreventive possibility. (1)
Anti-cancer: Study isolated a new ring-A secotriterpene, koetjapic acid, and five known compounds. Two compounds exhibited significant cytotoxic activity against cultured human cancer cells. (2)
Anti-inflammatory: Stem extract study yielded 3-oxo-12-oleanen-29-oic acid and katonic acid which showed anti-inflammatory activity equivalent to indomethacin. (3)
DNA Polymerase B Inhibition: Study isolated three compounds. Compounds 1 and 2 with derived derivatives 11, 12, and 13 showed activity against DNA polymerase B. (4)
Termite Repellent: Although the research product was not quick in killing termites. it was as good as the commercial product in repelling them. It also showed to be environmentally friendly, organic, lacking unpleasant odors and containing no dangerous chemicals. (6)
Antiangiogenic / Koetjapic Acid: Study isolated koetjapic acid, a seco-A-ring oleanene triterpene. Results suggest the non-cytotoxic compound, KA, may be a potent antiangiogenic agent; its activity. (9)
Breast Cancer / Cytotoxic / Apoptotic: A n-hexane extract showed dose-dependent cytotoxic and apoptotic activities on all breast cancer cell lines. Study provides evidence for the presence of an effective anticancer agent in the stem bark of S. koetjape. (10)
Topical Anti-Inflammatory Effect / Stem Extracts: Anti-inflammatory effect of stem extracts was investigated on topical administration in a TPA-induced mouse ear inflammation model. Fractionation of active fractions isolated 3-oxo-12-oleanen-29-oic acid and katonic acid as the biotic principles responsible for the anti-inflammatory activity. The inhibition effect was almost equivalent to indomethacin. (13)
Cytotoxic / Anti-Angiogenic: An n-hexane extract of stem bark of S. koetjape was investigated for cytotoxic and anti-angiogenic properties in an invitro cell proliferation assay. In a rat aorta ring assay, study showed inhibition of outgrowth of blood vessels from rat aorta rings. Extract also showed dose-dependent growth inhibition of all tested cell lines. At 50 µg mL, there was potent induction of apoptotic cell death of HCT-116 colon cancer cell line by inducing caspases activity. Results showed anti-angiogenic and apoptotic properties on colon cancer cell line. (14)
Breast Cancer / Cytotoxic / Apoptotic / Stem Bark: Study evaluated cytotoxic and apoptotic properties of stem bark in an invitro cell proliferation assay on three breast cancer cell lines and one normal cell line. The n-hexane extract exhibited dose-dependent growth inhibition of all tested cell lines. At 100 µg m, there was induced apoptotic cell death by inducing activity of effector caspases. Results suggest S. koetjape is a good candidate for further research targeting cancer treatment. (15)
Saintlier Acid / Cytotoxic Tritpenoids / Human Promyelocytic Leukemia HL-60 Cells: Study isolated a new ring A-seco triterpenoid, sentulic acid, along with a known oleanane-type triterpenoid, 3-oxoolean-12-en-27-oic acid. Cytotoxic activity was studied on human promyelocytic leukemia HL-60 cells. Results showed the compound were able to induce cytotoxicity through apoptosis. (16)

Availability
Wild-crafted.
Cultivated for its fruit.
 

Last Updated August 2013

Photos ©Godofredo Stuart / StuartXchange
IMAGE SOURCE / File:Sandoricum koetjape Blanco1.127-cropped.jpg / Flora de Filipinas / Franciso Manuel Blanco (OSA), 1880-1883 / Public Domain/ Modifications by Carol Spear / Wikimedia Commons

Additional Sources and Suggested Readings
(1)
Ichthyotoxic and Anticarcinogenic Effects of Triterpenoids from Sandoricum koetjape Bark / Biological & Pharmaceutical Bulletin
Vol. 26 (2003) , No. 9 1351/ doi:10.1248/bpb.26.1351
(2)
Plant anticancer agents, L. cytotoxic triterpenes from Sandoricum koetjape stems / Norito Kaneda, John M. Pezzuto, A. Douglas Kinghorn, Norman R. Farnsworth et a / J Nat Prod. 1992 May;55(5):654-9.
(3)
Antiinflammatory activity of stem extracts of Sandoricum koetjape / M A Rasadag et al / Phytomedicine, Volume 11, Issue 2, Pages 261-263
(4)
DNA Polymerase β Inhibitors from Sandoricum koetjape / Di-An Sun et al / J. Nat. Prod., 1999, 62 (8), pp 1110–1113 / DOI: 10.1021/np990104r
(5)
Modified limonoids from the leaves of Sandoricum koetjape / Intan S Ismail et al / Phytochemistry
Volume 64, Issue 8, December 2003, Pages 1345-1349 / doi:10.1016/S0031-9422(03)00500-4
(6)
Sandoricum koetjape (Santol) Tree Bark Extract as Pesticide-Repellant for Termites / Michael Janus Manzano / Research Project • Rizal National Science High School

(7)
Two new limonoids from the leaves of Sandoricum koetjape / Orasa Pancharoen, Anchalee Pipatanapatikarn, Walter Charles et al / Natural Product Research, Vol 23, No 1, 2009 / /DOI:10.1080/14786410601133426
(8)
The Pharmacological Properties Of Terpenoids From Sandoricum Koetjape / Zeyad D. Nassar, Abdalrahim A.F. Aisha , Amin Malik Shah Abdul Majid / WebmedCentral COMPLEMENTARY MEDICINE, 2010;1(12):WMC001311
(9)
Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr / Zeyad D Nassar, Abdalrahim FA Aisha, Mohamed BK Ahamed et al / Cancer Cell International 2011, 11:12 / doi:10.1186/1475-2867-11-12
(10)
In vitro Cytotoxic and Apoptotic Properties of the Stem Bark of Sandoricum koetjape on Breast Cancer Cells
/ A F A Aisha, S A Alrokayan et al / International Journ of Cancer Research, 5(3):123-129, 2009
(11)
The use of medicinal plants by Ifugao-migrants in the foothills of the Sierra Madre mountain range / Jasper Wester
(12)
Sandoricum koetjape (Kechapi) / Common names / ZipcodeZoo
(13)
Anti-inflammatory agents from Sandoricum koetjape Merr. / M A Rasadah, S Khozirah, A A Aznie, M M Nik / / Phytomedicine, 11(2-3):261-3. / DOI:10.1078/0944-7113-00339
(14)
Cytotoxic and Anti-Angiogenic Properties of the Stem Bark Extract of Sandoricum koetjape / A.F.A. Aisha, H.B. Sahib, K.M. Abu-Salah, Y. Darwis and A.M.S. Abdul Majid / International Journal of Cancer Research, 2009, Volume: 5, No 3, pp 105-114. / DOI: 10.3923/ijcr.2009.105.114
(15)
In vitro Cytotoxic and Apoptotic Properties of Stem Bark Extract of Sandoricum koetjape on Breast Cancer Cells / A F A Aisha, S A Alrokayan, K M Abu-Salah, Y. Darwis, and A M S Abdul Majid / International Journal of Cancer Research 5(3): 123-129, 2009.
(16)
Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr / Mai Efdi Masayuki Ninomiya Erma Suryani Kaori Tanaka Sanusi Ibrahim Kunitomo Watanabe Mamoru Koketsu / Bioorganic & Medicinal Chemistry Letters, 2012 | 22 | 13 | 4242-4245


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