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Family Cyperaceae
Mutha
BOTO-BOTONES
Cyperus rotundus
NUT GRASS
Hsiang-fu

Scientific names Common names  
Cyperus rotundus Linn. Balisanga (Ilk.)  Omadiung (Pamp.)
Cyperus hexastachys Rottb. Barsanga (Ilk.) Onoran (Pamp.) 
Cyperus curvatus Llanos Boto-botones (Bik.)  Sur-sur (Pamp.) 
  Galonalpas (Pamp.) Tarugug (Bik.)
  Kusung (Pamp.)  Hsiang-fu (Chin.)
  Mala-apulid (Pamp.) Nut grass (Engl.)
  Mota (Pamp.)  Coco grass (Engl.)
  Mutha (Tag.)  Nutsedge (Engl.)
Boto-botonesan or phonetic variations are shared by three plants of different species: (1) Mutha (Cyperus rotundus) Boto-botones (2) Gatas-gatas (Euphorbia hirta) botobotonis, botbotonis, botonis (3) Botoncillo (Gomphrena globosa) botbotonis, botones-botonesan.

Botany
· Slender, erect, glabrous, perennial grasslike plant, 10 to 40 cm high. Rhizomes or underground stems wiry, bearing black, hard, ovoid tubers about 1 cm in diameter. Above ground stem solitary, distinctly 3-angled.
· Leave as long as the stems.
· Flowers: inflorescence umbel-type, simple or compound, 2 to 6 cm long, with rather long rays or spikes. Spike with 3 to 8 spikelets. Spikelets brown, flat, slender, 10 to 25 mm long with 10 to 25 florets per spikelet. Rachilla of the spikelet distinctly winged. Glumes of the floret distichously arranged, the first 2 empty, the third one bisexual.
· Fruits: 3-angled nuts.

Distribution
Found throughout the Philippines; a common weed in gardens, lawns and wastelands.throughout the Philippines.


Part utilized
· Rhizome.
· Harvest from December to January.
· Wash and sun-dry or heat-dry in a clean frying pan.
· Scrape off the fibrous roots.

Constituents and Characteristics Effects
• Norcyperone, a novel norsesquiterpene isolated from CR.

A study of the constituents of the essential oil of Cyperus rotundus yielded three new sesquiterpene hydrocarbons and a ketone (cyperadione).
• Constituents include 1,8-cineole, 4alpha,5alpha-oxidoeudesm-11-en-3-alpha-ol, Alkaloids, Alpha-cyperone, Alpha-rotunol, Beta-cyperone, Beta-pinene, Beta-rotunol, Beta-selinene, Calcium, Camphene, Copaene, Cyperene, Cyperenone, Cyperol, Cyperolone Cyperotundone D-copadiene, D-epoxyguaiene, D-fructose, D-glucose, Eo, Flavonoids, Gamma-cymene, Isocyperol, Isokobusone, Kobusone, Limonene, Linoleic-acid, Linolenic-acid, Magnesium, Manganese, Mustakone, Myristic-acid, Oleanolic-acid, Oleanolic-acid-3-o-neohesperidoside, Oleic-acid, P-cymol, Patchoulenone, Pectin, Polyphenols, Rotundene, Rotundenol, Rotundone, Selinatriene, Sitosterol, Stearic-acid, Sugeonol, Sugetriol.

Properties
• Fragrant, slightly bitter tasting rhizome.
• Considered analgesic, alternative, astringent, antispasmodic, antibacterial, carminative, contraceptive, demulcent, emmenagogue, emollient, febrifuge, immunostimulant, laxative, stimulative, tonic, vermifuge.

Uses
Folkloric
· Indigestion and constipation: 2 to 6 gms of dried material in a standard cup of water, boil to concentration and drink.
· Skin diseases: Wash the diseased portion with the hot decoction.
· Chest pains caused by deterred blood flow of blood and energy circulation: boil to decoction 4 to 9 gms of dried drug preparation together with 4 gms of Citrus (dalanghita, kahel, suha, kalamansi, etc.) and drink.
· Neurogenic gastralgia, abdominal distention, heaviness at the chest, acidic vomiting: 3 to 9 gms dried material in decoction.
·Irregular menstruation, painful menstruation: 3 to 9 gms dried material in decoction.
· Sprains and bruises, furuncle infections: Use pounded fresh material as poultice or cook the pulverized drug material in vinegar and apply as hot poultice.
- In various oriental traditional systems, rhizomes used for stomach and bowel disorders.
· In Ayurveda, used for leprosy, fever, dysentery, itching, and as anthelmintic.
· In India, used for wound healing.
· In Unani, used for ulcers and sores, fevers, dyspepsia.
Others
• Elsewhere, leaves used in the weaving of baskets and hats.

Studies
Antidiabetic / Antioxidant:
Antidiabetic activity of hydro-ethanolic extract of Cyperus rotundus in alloxan induced diabetes in rats: Extract study of CR significantly lowered the blood glucose levels and showed antioxidant activity and radical scavenging in vitro.
Cytoprotective: Cytoprotective effects of Cyperus rotundus against ethanol induced gastric ulceration in rats: Study suggests cytoprotective action is due to inhibition of gastric motility and endogenous prostaglandins.
Wound healing: Extract showed effects in wound healing parameters: contracting ability, wound closure time and tensile strength.
Stress-Reducing Effects: Physiological EffectsEffects of herbal mixture with Cyperus rotundus L. on blood pressure, norepinephrine, cortisol and psychological variables in healthy medical students under examination: Herbal mixture that included CR seems to help reduce stress-related physiological and psychological symptoms.

Anti-Hypertensive: Aqueous extract of C rotundus showed a hypotensive effect in rats probably acting both centrally and peripherally altering the peripheral resistance and cardiac mechanics. Phytochemical screening yielded tannins, saponins, carbohydrates and the absence of alkaloids, proteins and sterols.
Antimicrobial Activity: Study showed antimicrobial activity against K pneumonia, A niger and S aureus.
Mosquito Repellent: C rotundus extract was screened for repellent activity against mosquite vector Anopheles culicifacies, A stephensi, Culex quinquefasciatus. Study showed the tuber extracts to be more effective for repellency of all the mosquito verctors even at low dose. The extract can be applied as an effective personal protective measure against mosquito bites.
Polyphenols / Antioxidant: Study on the rhizome extract of Cyperus rotundus exhibited concentration-dependent scavenging effect on superoxide anion radicals, OH radicals, NO radicals, H2O2, metal chelating and reducing power. Results suggest CR rhizome extract can be a potential source of natural antioxidant.
Anti-Obesity Effect: Study of C rotundus tubers hexane extract for 60 days induced a significant reduction in weight gain without affecting food consumption or inducing toxicity. In vitro, the extract was able to stimulate lipolysis. The effect in weight gain may be partially mediated through activation of ß3-AR. Results suggest CR tuber extract has a potential as a herbal supplement for controlling body weight.
Anti-Candida Activity: Study of essential oils and ethanolic extracts of leaves and/or roots of 35 medicinal plants in Brazil were screened for anti-candidal activity. The essential oils of 13 plants, including Cyperus rotundus, showed anti-Candida activity.
Anti-Inflammatory: Study showed the methanol extract of rhizomes of CR showed inhibition of NO production in a dose-dependent manner from the suppression of iNOS protein, as well as iNOS mRNA expression. Results suggest a potential for the methanol extract to be developed as an anti-inflammatory agent for diseases mediated by overproduction of NO and O2-.
Gastroprotective: Study results indicate that CR extracts have gastroprotective effect against acute mucosal lesons induced by ischemia/reperfusion.
Antimutagenicity: Study shows the oil of CR does not seem genotoxic. The oil exhibited effects against both direct and indirect mutagens.

Availability
Wild-crafted.
Extracts, oil and tinctures in the cybermarket.

Last Update July 2010

Photo © Godofredo Stuart / StuartXchange

Additional Sources and Suggested Readings
(1)
Antidiabetic activity of hydro-ethanolic extract of Cyperus rotundus in alloxan induced diabetes in rats / ScienceDirect
(2)
Cytoprotective effects of Cyperus rotundus against ethanol induced gastric ulceration in rats / Zhu M et al / PTR. Phytotherapy research • 1997, vol. 11, no5, pp. 392-394
(3)
Wound healing activity of cyperus rotundus linn / Puratchikody A et al / Indian Journ of Pharmaceutical Sciences. Jan 1, 2006
(4)
Effects of herbal mixture with Cyperus rotundus L. on blood pressure, norepinephrine, cortisol and psychological variables in healthy medical students under examination
(5)

Composition of eleven herbals for treating cancer

(6)
Chemical study of the essential oil of Cyperus rotundus / Mesmin Mekem Sonwa and Wilfried A Konig /Phytochemistry • Volume 58, Issue 5, November 2001, Pages 799-810 / doi:10.1016/S0031-9422(01)00301-6
(7)
PHARMACOLOGICAL STUDIES ON TRADITIONAL MEDICINE (CYPERUS ROTUNDUS) USED IN PAKISTAN / Bin Rehman / PhD Thesis / Asif (2008) /
(8)
Evaluation of Hexane Extract of Tuber of Root of Cyperus rotundus Linn (Cyperaceae) for Repellency against Mosquito Vectors / S P Singh et al / Journal of Parasitology Research • Volume 2009 (2009) / doi:10.1155/2009/908085

(9)
In Vitro Antioxidant Activity and Total Polyphenolic Content of Cyperus rotundus Rhizomes
/ K R Nagulendran et al / E-Journal of Chemistry • Vol. 4, No.3, pp. 440-449, July 2007
(10)
Administration of Cyperus rotundus tubers extract prevents weight gain in obese Zucker rats / Bernard Lemaure et al / Phytotherapy Research • Volume 21 Issue 8, Pages 724 - 730
/ DOI 10.1002/ptr.2147
(11)
TIRIRICA (Cyperus rotundus) / Tropical Plant Database / Raintree Nutrition
(12)
Anti-Candida activity of Brazilian medicinal plants / Marta Cristina Teixeira Duarte, Glyn Mara Figueria et al /
Journal of Ethnopharmacology, Vol 97, Issue 2, 28 February 2005, Pages 305-311 / doi:10.1016/j.jep.2004.11.016 |
(13)
Inhibitory effects of methanol extract of Cyperus rotundus rhizomes on nitric oxide and superoxide productions by murine macrophage cell line, RAW 264.7 cells / Won-Gil Seo, Hyun-Ock Pae et al / Journal of Ethnopharmacology, Vol 76, Issue 1, June 2001, Pages 59-64 / doi:10.1016/S0378-8741(01)00221-5 |
(14)
Gastroprotective Effect Of Cyperus rotundus Extract against Gastric Mucosal Injury Induced by Ischemia and Reperfusion in Rats / Muhammet E Guldur, A Ozgonul et al / J. Pharmacol., 6: 104-110, 2010
(15)
Chemical Composition, Antibacterial and Antimutagenic Activities of Essential Oil from (Tunisian) Cyperus rotundus / Kilani, Soumaya; Abdelwahed Afef et al / Technology Publications



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